The Correlation Study Between Cytoplasmic Antineutrophil Cytoplasmic Antibody(c-ANCA)and Stroke

Objective:The occurrence of stroke is closely related to cerebrovascular conditions.Studies have found that antineutrophil cytoplasmic antibodies(ANCA)can cause the destruction of vascular wall,and the cytoplasmic antibodies(c-ANCA)can also increase the incidence of vasculitis,Therefore,this paper will explore the relationship between c-ANCA in ANCA and the incidence of stroke,and further explore the relationship between c-ANCA and its hemorrhagic diseases,so as to guide the clinical diagnosis and treatment.Methods:By reviewing the medical records through his system,1020 stroke patients hospitalized in our hospital from January 2019 to January 2020 were selected as the experimental group,and 203 physical examinees in the same period were randomly selected as the healthy control group.The incidence of ANCA was compared between the two groups.Chi square test showed that ANCA was correlated with the occurrence of stroke.ANCA includes cytoplasmic antibody(c-ANCA)and perinuclear anti cytoplasmic antibody(p-ANCA).In order to explore the relationship between c-ANCA and stroke in ANCA,the incidence of c-ANCA in the two groups was compared according to the detection results of c-ANCA,and chi square test was conducted again to verify the correlation between c-ANCA and stroke.To further explore the relationship between c-ANCA and hemorrhagic stroke,the experimental group was divided into hemorrhagic stroke group and ischemic stroke group.The clinical data were collected and multivariate logistic regression analysis was conducted to verify that c-ANCA is an independent risk factor for hemorrhagic stroke.Results:The positive rate of ANCA in the experimental group was higher than that in the healthy control group(11.86% vs 6.40%,P < 0.05);The positive rate of c-ANCA in the experimental group was higher than that in the healthy control group(5.88% vs 2.50%,P < 0.05);Through further study on 1020 stroke patients,through multivariate regression analysis,c-ANCA was an independent risk factor for hemorrhagic stroke,and the risk probability of hemorrhagic cerebrovascular events in patients with c-ANCA was increased(or = 3.52,95% CI: 1.97-6.27),P < 0.05.Conclusion:There is a correlation between c-ANCA and the incidence rate of stroke.C-ANCA may be an independent risk factor for hemorrhagic stroke,and c-ANCA is more important in detecting hemorrhagic stroke in young people.