Clinical Study On The Effect Of Chinese Herbal Compound Xueduqing On Sepsis Associated Acute Kidney Injury

1.Purpose Objective to investigate the intervention effect of Xueduqing on patients with sepsis associated acute kidney injury,and evaluate the clinical efficacy by comparing the inflammatory index,renal function index,coagulation function index,prognosis score and endpoint index before and after treatment.2.Method40 patients with SA-AKI are from the ICU of the First Affiliated Hospital of Anhui University of TCM from December 2019 to December 2020 were randomly divided into control group and treatment group with 20 cases in each group.The two groups were both given routine western medicine treatment according to the Chinese guidelines for emergency treatment of sepsis/septic shock in 2018.The treatment group was given additional Chinese herbal compound Xueduqing.Record the inflammatory indexes,renal function indexes,coagulation function index,prognosis score,End point before and after treatment 7 days.IBM SPSS 22.0 was used for statistical analysis,with P≤0.05 as the difference was statistically significant.3.Results(1)There was no difference between the two groups in baseline indicators(P>0.05).(2)There were differences in WBC,NEU%,CRP,PCT and IL-6 between the two groups after treatment(P≤0.05),and the treatment group was lower than the control group.(3)There were differences in BUN,UA,NGAL,Cys C between the two groups after treatment(P≤0.05).No significant difference in SCR and UOP in the control group before and after treatment(P>0.05).SCR and UOP of the treatment group after treatment were different from those before(P≤0.05).The difference between the two groups was significant(P≤0.05),and the treatment group was better than the other group.(4)PT and APTT of the two groups after treatment were different from those before(P≤0.05).No difference in FIB and D-D in the control group before and after treatment(P>0.05).FIB and D-D in the treatment group were different after treatment(P≤0.05).The difference between the two groups was significant(P≤0.05),and the treatment group was better than control group.(5)There were differences in SOFA,APACHE II and TCM syndrome score between the two groups after treatment(P≤0.05).The difference between the two groups was significant(P≤0.05),and the treatment group was better than the control group.(6)The 28 day and 90 day mortality in the treatment group were lower than the control group,and the difference was statistically significant(P≤0.05).(7)The total effective rate of the treatment group was higher than the control group,and the difference was statistically significant(P≤0.05).4.ConclusionRoutine western treatment combined with Xueduqing could reduce the inflammatory reaction,improve the renal function and coagulation function,alleviate the disease condition and improve the prognosis,prolong the survival time,reduce the clinical symptoms and improve the clinical efficacy in patients with sepsis associated acute kidney injury.