Clinical Characteristics Of COVID-19

Objective:To analyze the clinical characteristics of patients with COVID-19 complicated with multiple infections.to explorer the high risk factor of COVID-19 complicated with multiple infection and to analyze Clinical characteristics of patients with basic diseases.Methods:retrospective analysis was performed on COVID-19 patient admitted to the isolation Word of Dongfeng General Hospital from January to March 2020,including 41 male and 42 femal,According to whether the patients were infected with other pathogens,they were divided into multiple infection group A and only SARS-COV2 infection group B.According to whether the patients were infected with basic diseases,they were divided into complicated basic diseases group C and no complicated basic diseases group D.They were divided into common type and severe type according to the severity,the differences in age,gender,basic disease,smoking history,day from onset to visit the doctor,and disease severity between group A and group B were compared,The laboratory test results of group A and group B were compared as follows : C-reactive protein,White blood cells,Neutrophils,lymphocytes,Ferritin,Procalcitonin,Albumin,Alanine aminotransferase,Aspartate aminotransferase,Creatine kinase,Lactate dehydrogenase,creatinine,urea,,D-2polymeric body,erythrocyte sedimentation rate,and risk factors of COVID-19 complicated with multiple infections were analyzed.,the differences in onset to see a doctor,hospital stay,the proportion of male patients,and age between group C and group D were compared,The laboratory test results of group A and group B were compared as follows: lymphocyte count,white blood cell count,neutrophil count,c-reactive protein,iron,protein,calcitonin,albumin,glutamate amino transferase,aspartate aminotransferase,creatine kinase,lactate dehydrogenase,urea,creatinine,blood sedimentation,D-2 polymers,Chest CT characteristics.A total of 83 patients were included in the study.The patients ranged from 18 to 78 years old,and all recovered and discharged.All patients were treated in accordance with the relevant diagnosis and treatment plan published by the National Health Commission during hospitalization,mainly including antiviral,antibiotic,oxygen therapy,glucocorticoid,symptomatic relief and supportive treatment.Results:There was no significant difference in sex,age and basic diseases between A、B groups(P>0.05);There was no significant difference in day from onset to visit the doctor between A、B two groups(P>0.05);and there was no significant difference in the proportion of common and severe patients(P>0.05).The initial value of C reactive protein(CRP)in the A group was higher than that in the B group(P<0.001);there was no significant difference in other indexes such as leukocyte,neutrophil,lymphocyte,ferritin,calcitonin,albumin,alanine aminotransferase,aspartate aminotransferase,creatine kinase,lactate dehydrogenase,creatinine,urea,D-2polymer,erythrocyte sedimentation rate(P>0.05);Dynamic monitoring of the changes of inflammatory markers in two groups,The CRP extreme value of A group was higher than that of B group(P<0.001).while in hospital,There was significant difference between the extreme value of procalcitonin(PCT)in A group and B group(P<0.01).The extreme value of lactate dehydrogenase(LDH)in A group was higher than that in B group(P=0.01).There was no significant difference in the extrema value of the remaining(white blood cells,neutrophils,lymphocytes,ferritin,albumin,alanine aminotransferase,aspartate aminotransferase,creatine kinase,creatinine,urea,D-2polymer,erythrocyte sedimentation rate)during hospitalization(P>0.05).Use of Logistics analysis to show basic disease(OR=1.448 95% CI=0.370~5.668,P<0.001),history of smoking(OR=0.279 95%CI=0.024~3.308,P=0.021)and LDH(OR=4.37895% CI=2.033~9.429,P<0.001)is an independent risk factor for COVID-19 patients complicated with multiple pathogens.Among C group patients with basic diseases,Higher percentage of male patients than D,However,there was no significant difference(P=0.818);Age was higher than D group,And the difference was significant(P<0.001).onset to admission(3.5d)shorter than D group of patients without basic disease(4.0d),A significant difference(P=0.046);Proportion converted to severe shorter than D group,But the difference was not significant(P=0.675).C group had shorter hospital stay than the D group,difference was significant(P=0.032).Neutrophil counts were higher in C group than in D group,Differences were significant(P=0.030);Ferritin was higher than D group,Differences were significant(P=0.039);Calcitonin was higher than D group,difference was significant(P<0.05);Creatinine,urea nitrogen were higher than D group,A significant difference(P=0.017);The ESR was higher in C group than in D group,Differences were significant(P=0.003);The other observation indexes were not statistically significant.C group had a higher creatinine extreme value than the D group,Differences were significant(P=0.015);C group had higher urea extreme value than D group,Differences were significant(P=0.014);The ESR of C group was higher than that of D group,Differences were significant(P=0.011);C group of patients in hospital found lesions to lung lesions began to absorb shorter than D group,A significant difference(P=0.000),The other observation indexes were not statistically significant.Conclusion:Patients with corona virus disease 2019(COVID-19)with a history of smoking are more likely to be infected with other pathogens,with mild elevation of CRP in the early stage,and CRP、PCT、LDH elevation may occur when the condition progresses.Associated with basic disease,smoking history,LDH rise is a high risk factor for co-infection.COVID-19 patients with basic diseases are mostly elderly people,and the time to visit and stay in hospital is shorter,more susceptible to infection with other pathogens,NEUT、ferritin、CRP、ESR abnormalities are more common,more likely to have kidney damage,lung lesions absorb faster after active treatment...