Clinical Analysis Of HBsAg And Nucleotide (Acid) Analogues In HBV Infection-related Liver Disease

Objective:1.To detect and analyze the level of surface antigen（HBsAg）and quantitative HBV DNA in patients with liver cancer associated with chronic viral hepatitis B infection,and to explore the correlation between surface antigen（HBsAg）level and HBV DNA quantification and liver cancer in patients;2.To analyze the clinical efficacy of nucleoside analogues in the treatment of chronic hepatitis B patients.Significance:To explore the significance of early prediction and treatment of hepatitis B associated hepatocellular carcinoma.Data and Methods:From January 1^st 2010 to December thirty-one 2015,294newly diagnosed patients who did not receive antiviral treatment in the Infection Department of the First Affiliated Hospital of Lanzhou University were enrolled.According to the results of"serology+imaging",they were divided into two groups:117 cases of chronic hepatitis B;There was no significant difference in sex ratio and age in 177 cases of liver cancer group.Among them,60 patients in the chronic hepatitis B group were treated with nucleoside analogues and divided into groups.Results:1.In the chronic hepatitis B group,male patients accounted for64.9&female patients accounted for 35.1%;in the liver cancer group,male patients accounted for 80.7%and female patients accounted for 19.3%,indicating that male patients were more likely to be infected with HBV than female patients,and the proportion of disease progression to liver cancer was also high;2.The age distribution of HCC group was（46.99±15.02）,and that of HCC group was（50.94±9.66）.The age of HCC group was older than that of HCC group,suggesting that age may be one of the influencing factors of HCC.When analyzing the relationship between HBsAg and gastric fundus red sign and liver cancer,there was statistical significance on the level（P<0.05）.2.The level of HBsAg and HBV DNA viral replication loads the relationship in the two groups of data are statistically level analysis of the significance（P<0.05）,in patients with CHB group,the serum level of HBsAg and HBV DNA viral replication loads present negative correlation（r=0.198）,in liver cancer group,the patients serum level of HBsAg and HBV DNA viral replication loads present positive correlation（r=0.168）,can explain in liver cancer group,the higher the value of HBsAg,and the higher levels of HBV DNA.3.In the group that had never received antiviral therapy,entecavir（ETV）and adefovir dipivoxil（ADV）were not statistically significant in either virological or serological responses at the end of 48 weeks（P>0.05）.Conclusion:1.The higher the male,the older the age,the higher the HBsAg,the higher the risk of HCC,and the lower the risk of HCC without fundus red sign;Serum HBsAg titer level of patients will gradually increase with the progression of hepatitis B disease to liver cancer.HBsAg has a high significance in the development of liver cancer evaluation.2.In the slow hepatitis B group,the patient HBsAg titer level was negatively associated with the HBV DNA virus replication load（r=-0.198）and the positive correlation with the HBV DNA virus replication load in the liver cancer group（r=0.168）,and the activity and replication of HBV could be monitored jointly.Serum HBV DNA levels at>10,000copies/m L and<10,000copies/m L showed no statistically significant difference in mortality.3.In untreated CHB patients,entecavir and adefovir dipivoxil treated up to 48 weeks respectively did not differ in delaying disease progression and improving survival.