Analysis Of Influencing Factors Of Acute Bilirubin Encephlopathy In Neonates With Severe Hyperbilirubinemia

Objective:To explore the related clinical factors of acute bilirubin encephalopathy(ABE)in severe neonatal hyperbilirubinemia,and to seek ways to reduce the incidence of ABE,so as to provide a beneficial reference for the clinical diagnosis and treatment of ABE.Method:Clinical data of neonates with severe hyperbilirubinemia(serum total bilirubin > 342 μmol/L)were collected from the First Hospital of Lanzhou University from January 2018 to May 2020,including basic information,concomitant diseases,and laboratory examination indexes.The subjects were divided into ABE group and non-ABE group according to the occurrence of ABE.Statistical analysis was conducted on the clinical data of the two groups of children.The variables with statistical differences in univariate analysis were included in multivariate logistic regression analysis again,and P≤0.05 was used to indicate that the differences between the two groups were statistically significant.Results:A total of 123 children with severe hyperbilirubinemia were included,including 28 in ABE group and 95 in non-ABE group.Single factor analysis showed that childbirth way,feeding way between the 2 groups,along with the disease,hematocrit,hospitalization days,total bilirubin,hemoglobin value difference was statistically significant(P≤0.05),the single factor analysis results meaningful are incorporated into the Logistic regression analysis showed that high hemoglobin levels(OR=1.032,95% CI 1.007～1.057),is a risk factor for ABE,breast-feeding is a possible protection factor for ABE(OR= 0.151,95%CI 0.028 ～0.821).Conclusion:Severe hyperbilirubinemia with high hemoglobin levels should be highly alert to the occurrence of ABE,and strengthening breastfeeding education and guidance may be helpful to prevent the occurrence of ABE.