Correlation Of Renal Function,Blood Lipids And Homocysteine Levels With Parkinson’s Disease And White Matter Lesions

Part 1: The correlation study of blood urea nitrogen,creatinine level and proteinuria with Parkinson’s diseaseBackground Parkinson’s disease is related to renal insufficiency,and the role of blood urea nitrogen,creatinine and proteinuria in the development of PD has not been extensively studied.The purpose of this study is to explore the correlation between blood urea nitrogen,creatinine and proteinuria and PD.Methods 200 PD patients who visited the Parkinson’s Dyskinesia Clinic in our hospital from January 2015 to January 2020 were selected as the PD group,and 110 healthy patients from the health examination center during the same period were selected as the control group.Determine the levels of biochemical indicators in each group,and compare and analyze these biomarkers with clinical data.Results The levels of cholesterol(TC),triglycerides(TG),low-density lipoprotein(LDL-C),and apolipoprotein B in the PD group were lower than those in the control group.The levels of creatinine,urea nitrogen and urineprotein in the PD group were higher than those in the control group.Multivariate logistic regression analysis showed that elevated blood urea nitrogen,creatinine,and urine protein levels were risk factors for PD,and elevated LDL-C levels were protective factors for PD.The AUC of urea nitrogen to PD was 0.680(95%CI: 0.617~0.742,P<0.00).The AUC of creatinine to PD was 0.673(95%CI: 0.613~0.733,P < 0.00).The blood urea nitrogen level of PD patients is positively correlated with the course of PD,Hoehn-Yahr staging and UPDRS exercise score(r=0.309,r=0.434,r=0.540,P<0.01),and the level of blood creatinine is correlated with the course of PD,Hoehn-Yahr There was a positive correlation between staging and UPDRS exercise score(r=0.139,r=0.320,r=0.290,P < 0.01).Conclusion Blood urea nitrogen,elevated creatinine levels and proteinuria may be independent risk factors for the occurrence of Parkinson’s disease in the elderly.Blood urea nitrogen and creatinine levels have a certain predictive effect on the onset of PD.Early renal protection may reduce the risk of PD and slow down the progression of PD.Part2: Correlation study between serum homocysteine and blood lipid levels and white matter lesions in patients with Parkinson’s diseaseObjective To search for risk factors for patients with Parkinson’s disease(PD)complicated by leukoencephalopathy(WML).Methods 200 PD patients who visited the Parkinson’s Dyskinesia Clinic in our hospital from January 2015 to January 2020 were selected as the PD group,and 110 healthy patients from the health examination center during the same period were selected as the control group.Collect medical history and demographic data to determine the level of biochemical indicators in each group.Compare and analyze these biomarkers with clinical data.Results The level of Hcy and the incidence and severity of WML in the study group were higher than those of the control group,and the blood lipid level was lower than that of the control group.As the severity of WML increased,the levels of Hcy and cystatin C showed an upward trend,TC,HDL-C and apolipoprotein A showed a downward trend,while the course of disease,HY score and UPDRS exercise score showed an upward trend;Hcy and WML were positively correlated.After adjusting for demographics and confounding factors,the Hcy level is still positively correlated with the severity of WML.The AUC of Hcy on WML in PD patients is 0.7167(95%CI: 0.673~0.861,P<0.01);Conclusion Elevated blood Hcy level may be an independent risk factor for PD patients with WML,and elevated HDL-C level is a protective factor for PD patients with WML;Hcy may be used as a biomarker for PD patients with WML.