The Effect Of High Frequency Repetitive Transcranial Magnetic Stimulation On Mild Cognitive Impairment In Early Parkinson’s Disease

Objective:Use ERP-P300 and MOCA to evaluate the changes of cognitive functi on after high frequency Repetitive Transcranial Magnetic Stimulation in Early Par kinson’s disease with Mild cognitive impairment patients.To investigate the clinica l efficacy of high frequency repetitive transcranial magnetic stimulation on mild cognitive dysfunction in patients with early Parkinson’s disease.Methods:The subjects came from the patients who were diagnosed with Early Parkinson’s disease with Mild cognitive impairment in Department of Neurology,Anqing Hospital Affiliated to Anhui Medical University in December 2018 to May 2020.Analysis of their sex,age,education level,anxiety and depression and other related factors,selecting 60 patients who whin eligible early Parkinson’s disease patients with mild cognitive dysfunction.They were assigned to the experimental group and the control group,30 cases in each group.The dorsolateral cortex of the left prefrontal lobe is the stimulation area.The r TMS group was treated with 10 HZ high-frequency repeated transcranial magnetic stimulation,and the control group was treated with pseudo-stimulation.The MOCA scale score and P300 change of the two groups before and after treatment were compared.Results:After treatment,the total score of MOCA scale(22.07 ± 1.48)and P300amplitude(7.95 ± 1.89)of r TMS treatment group were higher than those of control group(21.10 ± 1.49)and(6.85 ± 1.92),and the P300 latency(325.18 ± 17.73)was shorter than that of control group(334.87 ± 18.95),the difference was statistically significant(t=2.51,P<0.05,t=2.24,P<0.05,t=2.04,P<0.05).The results indicated that the cognitive function of r TMS treatment group was significantly improved compared with the control group.After treatment,the memory item score of r TMS treatment group(3.53 ± 0.68)was higher than that of control group(3.07 ± 0.83),the difference was statistically significant(t=2.38,P<0.05).The improvement in memory after repeated transcranial magnetic stimulation was greater in the r TMS group than in the control group.Conclusion:As the results,High-frequency repetitive transcranial magnetic stimulation can improve mild cognitive function in patients with early Parkinson’s disease,and it is mainly reflected in improving memory ability.