Correlation Analysis Of The Level Of Macrophage Migration Inhibitory Factor And Intercellular Adhesion Molecule-1 With Intracranial And Extracranial Atherosclerosis

BackgroundCerebral infarction is a common disease that is very harmful to human health.In recent years,the incidence has gradually increased,and the age of patients with stroke has gradually decreased.It is very important to prevent the occurrence and development of cerebral infarction.Large artery atherosclerotic(LAA)acute cerebral accident has the highest clinical incidence,and its main pathological basis is atherosclerosis.According to some reports,macrophage migration inhibiting factor(MIF)and intercellular adhesion factor-1(ICAM-1)are closely related to the formation of coronary and extracranial atherosclerosis.And they also play an important part in the formation of vulnerable plaques.However,there are no reports on the association between the levels of blood MIF,ICAM-1 and intracranial atherosclerotic stenosis(ICAS)in patients with LAA cerebral infarction.ObjectiveExploring the correlation between the levels of blood MIF and ICAM-1 and intracranial atherosclerosis in patients with LAA cerebral infarction,and the relationship between the levels of blood MIF,ICAM-1 and vulnerable plaques in extracranial arteries.MethodsFrom May 2019 to February 2020,260 patients with LAA type cerebral infarction were treated in neurology department of the first Affiliated Hospital of Xinxiang Medical College.All patients underwent magnetic resonance plain scan with magnetic resonance angiography(MRA)and carotid artery color doppler ultrasound.According to MRA,the subjects were divided into non-ICAS group and ICAS group(mild,moderate,severe).According to carotid artery color doppler ultrasound,the non-ICAS group whose responsible vessel was the extracranial artery were divided into stable plaque group and vulnerable plaque group.Enzyme linked immunosorbent assay(ELISA)was used to test the level of MIF,ICAM-1 between groups.The relationship between the level of plasma MIF,ICAM-1 and the degree of ICAS and the vulnerable plaque of extracranial arteries were further analyzed by Spearman correlation method.Results1.Compared with the group without ICAS,the levels of HCY,LDL,and Glu in the ICAS group were significantly increased,while the level of HDL was significantly reduced,and the differences were statistically significant(P<0.05).2.Compared with the non-ICAS group,the levels of plasma MIF and ICAM-1 in the ICAS group were significantly increased,and the difference was statistically significant(P<0.05).Spearman correlation analysis results showed that the levels of plasma MIF and ICAM-1 were positively correlated with the degree of intracranial arteriosclerosis(r=0.790,0.823,P<0.01);Pearson correlation analysis results showed that the levels of blood MIF and ICAM-1(r=0.677,P<0.01)were positively correlated.3.The ROC curve results of the levels of MIF and ICAM-1 to assess the intracranial atherosclerosis stenosis showed that the AUC value of MIF was 0.849,the sensitivity was0.723,the specificity was 0.931,and the best cut-off value was 190.15pg/m L;the AUC of ICAM-1 was 0.884,the sensitivity was 0.723,the specificity was 0.943,and the best cutoff value was 387.28 pg/m L.4.The results of multivariate logistic regression analysis showed: the levels of plasma MIF(OR=1.058,P<0.01),ICAM-1(OR=1.026,P<0.01),HCY(OR=1.344,P<0.01),Glu(OR=3.818,P<0.01)increased,and the level of HDL(OR=0.076,P<0.01)decreased were risk factors for intracranial atherosclerosis.5.In the non-ICAS group,the levels of blood MIF and ICAM-1 of the vulnerable plaque group were significantly higher than those of the stable plaque group,and the difference was statistically significant(P<0.05);Spearman correlation analysis showed that: the levels of blood MIF(r=0.826,P<0.01),ICAM-1(r=0.856,P<0.01)were significantly positively correlated with vulnerable plaques in extracranial arteries.Conclusions1.The levels of blood MIF and ICAM-1 increased are related to the degree of intracranial arteriosclerosis and stenosis,which are helpful to evaluate intracranial arterial stenosis and are risk factor for intracranial atherosclerosis in patients with LAA cerebral infarction.2.The levels of blood MIF and ICAM-1 increased are closely related to the formation of vulnerable plaques in extracranial arteries.