Meta-analysis Of The Diagnostic Value And Safety Of Endobronchial Cryobiopsy In Lung Neoplasms

Objective:To systematically evaluate the diagnostic yield and safety of cryobiopsy versus forceps biopsy for lung tumors.Methods:We conducted a comprehensive search of foreign databases such as EMBASE,Cochrane Library,Pub Med,as well as CNKI,Wanfang and other Chinese databases about the relevant studies of cryobiopsy in the diagnosis of lung tumors,and export to the Endnote literature manager.Literature included in the meta-analysis was screened according to the established inclusion criteria and exclusion criteria,extracted the data and present it as table,Rev Man5.3 was used for meta-analysis.The outcome indicators included: the diagnostic rate,specimen size,risk of bleeding.Results:Thirteen studies were included for meta-analysis,including three randomized controlled studies,two randomized before-after studies in the same patient,and eight non-randomized before-after studies.There were 876 cases in the EBCB group,868 cases in the TBFB group.The results showed that Compared with transbronchial forceps biopsy,the diagnostic rate of lung cancer in the cryobiopsy group was significantly higher(90.6% vs 77.4%),the difference was statistically significant(OR=3.56,95%CI 1.97-6.41,P<0.0001).Compared with forceps biopsy,cryobiopsy can obtain a larger sample size of tissue,the difference was statistically significant(MD=8.28,95%CI 3.97-12.58,P=0.0002).There was no difference in the total bleeding risk between cryobiopsy and forceps biopsy(OR=1.11,95%CI 0.65-1.89,P=0.70),but the incidence of moderate and severe bleeding risk was higher than forceps biopsy(OR=1.91,95%CI 1.32-2.75,P=0.0005).Conclusion1.we found that EBCB is more efficient than TBFB in the diagnosis of lung tumors.EBCB can obtain more high-quality tissue samples without mechanical compression and artifacts.2.Compared with TBFB,EBCB is relatively safe,However,there is an increased risk of moderate and severe bleeding...