Time Trends Of Helicobacter Pylori Prevalence And Upper Gastrointestinal Diseases Among Endoscopic Patients In Jiangxi

OBJECTIVE:To determine the change trends and distribution of Helicobacter pylori infection rate in patients from Jiangxi during the period from 1990 to 2019,and to explore the time trends of H.pylori-associated upper gastrointestinal disease.Methods:The endoscopic and pathological data of patients undergoing gastroscopy in the Endoscopy Center of The First Affiliated Hospital of Nanchang University from January 2016 to December 2019 were collected.The endoscopic data from the 1990 s were also collected.The prevalence of H.pylori and UGIDs were compared between the two periods,and the distribution of H.pylori in the population was analyzed.Results:1.A total of 121,595 patients were performed between January 2016 and December 2019(the second period),mean prevalence of H.pylori infection was31.6%.In the first period(1990-1992s),there were 2330 patients,with an average infection rate of 55.8%.A declining trend at an annual rate of 0.876% from 57.7% in1990 to 30.9% in 2019.The prevalence of H.pylori infection gradually increased with age.There was a gender difference in H.pylori infection,which was more common in males than females(33.5% vs.29.7%,P < 0.001).2.The detection rates of DU and GU all showed a decreasing trend,from 14.9%to 13.8% and from 8.5% to 3.9%,respectively.The detection rate of GC also decreased from 5.2% to 1.4%.In contrast,the RE detection rate increased from 1.4%to 4.4%.Conclusion:1.The prevalence of H.pylori infection rate was decreased each year in the past25 years.The infection rate decreases with age,and there was a difference between the gender.2.The detection rate of peptic ulcer and gastric cancer showed a decreasing trend,while reflux esophagitis showed an increasing trend,which was inversely associated with H.pylori infection.