Clinical Study On Early Intervention Of Infants’ Hearing Loss Caused By Cytomegalovirus Infection

Objective:To study the efficacy and adverse effects of Ganciclovir(GCV)in early intervention of cytomegalovirus(CMV)infection-induced hearing impairment in infants.Methods:A total of 100 children with HCMV infection and hearing impairment in infants who were admitted to the Department of Gastroenterology from January 2013 to October 2020 were collected through the electronic information management system of Jiangxi Children’s Hospital.All children were promoted by nutritional nerve and auditory stimulation methods.The residual hearing was restored,and informed consent was signed according to the wishes of the family members.70 patients who received ganciclovir treatment were in the ganciclovir group,and 30 patients who refused ganciclovir treatment were the control group.Among them,the ganciclovir group was in the above-mentioned treatment In addition,ganciclovir was treated for 3weeks,ganciclovir was given 5 mg/kg.times during the induction period,q12 h was treated for 2 weeks,and the rest was 1 week,and then ganciclovir was given 5 mg/kg.times,qd maintenance treatment 1 Week,3-6 months later,review the brainstem auditory evoked potential(BAEP)to evaluate its efficacy and recent side effects of ganciclovir.Results:1.In the ganciclovir group,52 cases(75%)were damaged in one ear and 18cases(25%)were damaged in both ears.In the control group,25 cases(83%)were damaged in one ear and damaged in both ears.5 cases(17%).2.In the ganciclovir group,53 cases(76%)were effective after treatment,17cases(24%)were ineffective,6 cases(25%)in the control group improved after treatment,and 24 cases(75%)were ineffective;The curative effect of Lovir group is better than the control group,P<0.05,the difference is statistically significant.3.In the ganciclovir group,45 cases(64%)were male,25 cases(36%)were female,53 cases(76%)were impaired in one ear,and 17 cases(24%)were impaired in both ears.After treatment,36 cases(80%)were effective in men,9 cases(20%)were ineffective,17 cases(68%)in women were effective,and 8 cases(32%)were ineffective.Compared with male and female curative effect,P>0.05,the difference was not statistically significant.4.In the ganciclovir group,there were 12 cases(17%)of children from January to March,of which 7 cases(58%)were effective after treatment,5 cases(42%)were ineffective,and 30 cases were children from March to June(43%),24 cases were effective(80%),6 cases were ineffective(20%),28 cases(40%)were children from6-12 months,22 cases were effective(79%),6 cases were ineffective(21%),each Compared with the age group,P>0.05,the difference is not statistically significant.5.Adverse reactions: Ganciclovir group: 2 cases of granulocytopenia(2.9%),4cases of anemia(5.7%),1 case of thrombocytopenia(1.4%);5 cases of liver damage(7.1%),the main ones There were 2 cases of ALT elevation(40%),3 cases of AST elevation(60%);1 case of allergic reaction,1 case of rash(1.4%);the above-mentioned adverse reactions,In the control group: 1 case of anemia(3.3%),1case of thrombocytopenia(3.3%),1 case of AST increased(3.3%),after symptomatic treatment and ganciclovir reduction Symptoms disappear after dose or discontinuation.Conclusion:1.In this study,ganciclovir combined with nutrient nerve and auditory stimulation method to promote residual hearing recovery was better than that of children with only nutrient nerve and auditory stimulation method to promote residual hearing recovery in infants with CMV infection.2.The efficacy of ganciclovir in the treatment of infant hearing impairment caused by CMV infection has nothing to do with the gender of the child and the age at the time of onset.3.The side effects of ganciclovir are small and reversible.The specific manifestations are neutropenia,anemia,thrombocytopenia,liver damage,skin rash and other adverse reactions.The symptoms disappear after symptomatic treatment and ganciclovir reduction or withdrawal.