Study On Characteristics And Analysis Of TCM Syndrome Elements Of Different Types Of Gastroesophageal Reflux Disease

Objective:Gastroesophageal Reflux Disease(GERD)is a kind of disease with related symptoms and(or)complications caused by reflux of gastric contents into esophagus,oral cavity and other parts.According to whether reflux causes esophageal mucosal erosion and ulcer,it can be divided into nonerosive reflux disease(NERD)and reflux esophagitis(RE).Re commonly used Los Angeles classification includes four types,including A,B,C and D.At present,there is no expert consensus to clarify whether there are differences in TCM pathogenesis,syndrome types and treatment of different types of GERD.Therefore,through syndrome differentiation,the characteristics of TCM syndrome elements of different types of gastroesophageal reflux disease are explored and compared,which provides a reference for TCM clinical diagnosis and treatment of different types of GERD.Methods:In this study,120 patients admitted to the Second People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine from January 2020 to February 2021 were collected.Through face-to-face questionnaire,the basic information of patients and four diagnostic information were collected,and the four diagnostic information was input into the syndrome element differentiation software to obtain the syndrome element score,so as to clarify the syndrome element characteristics of different types of GERD and carry out statistical analysis.Results:1.The pathological syndromes of GERD was mainly stomach,liver,spleen,and the primary pathogenic factors were stagnation of Qi,heat,humidity.The distribution of syndrome elements in each group showed that in NERD group,the pathological syndromes were stomach,liver,spleen,chest diaphragm,lung and heart spirit,and the pathogenic factors were stagnation of Qi,heat,humidity,yin deficiency,yang hyperactivity and blood stasis.The pathological syndromes of RE group were stomach,liver,spleen,lung,mind and chest diaphragm,and the pathogenic factors were qi stagnation,dampness,heat,yin deficiency,phlegm and blood stasis.In RE(Grade A)group,the main syndrome elements were stomach,liver,spleen,lung,chest diaphragm and mind,the pathogenic factors were qi stagnation,dampness,heat,yin deficiency,phlegm and yang hyperactivity.The pathological syndromes of RE(Grade B)group were stomach,liver,spleen,lung,heart,and mind,and the pathogenic factors were qi stagnation,phlegm,dampness,yin deficiency,heat and blood stasis.2.Through the comparison of syndrome elements in each group,it was found that there were differences between Nerd group and RE group(P﹤0.05):the pathological syndromes of spleen and heart,the actual syndromes of dampness,phlegm and blood stasis,and the deficiency syndrome of Yin deficiency,qi deficiency and Yang deficiency.There were differences in the pathological syndromes of spleen and heart,the actual syndromes of dampness and phlegm,and the deficiency syndrome of Yin deficiency between RE(Grade A)and RE(Grade B)groups(P﹤0.05).Compared with RE(grade B)and RE(grade A)group,the actual syndromes of phlegm were different between the two groups(P﹤0.05).Conclusion:1.Based on this study,the pathological elements of GERD are mainly the stomach,liver and spleen,and the pathological elements are mainly qi stagnation,heat and dampness.Treatment is based on the principles of transporting spleen and stomach qi,draining liver qi,and clearing heat and dampness.2.In the treatment of RE compared to NERD,those with deficiency should pay attention to strengthening the spleen and nourishing the heart,tonifying yin and yang,while those with actuality should pay attention to regulating qi and invigorating blood,resolving phlegm and dispelling dampness.3.In the treatment of RE(Grade A)compared to NERD,emphasis should be placed on strengthening the spleen,nourishing the heart,nourishing yin,and resolving dampness and dispelling phlegm.In the treatment of RE(Grade B)compared to RE(Grade A),emphasis should be placed on resolving phlegm.