| Objective To investigate the effects of early oral furosemide and spironolactone on MDA,s ST2,NT-pro BNP and cardiac function in patients with acute anterior wall myocardial infarction undergoing primary percutaneous coronary intervention,and to evaluate the value of furosemide and spironolactone in the early treatment of patients with acute anterior wall myocardial infarction.Methods From October 2019 to December 2020,62 patients with acute anterior wall myocardial infarction who underwent primary percutaneous coronary intervention were selected for treatment at the Chest Pain Center of Minda Hospital Affiliated to Hubei Minzu University,and they were randomly divided into control group(32 cases)and treatment group(30 cases).The control group was given aspirin,clopidogrel/ticagrelor,atorvastatin calcium tablets,angiotensin-converting enzyme inhibitor(ACEI),beta-blocker treatment.The treatment group was treated with a small dose of diuretics(10 mg furosemide per day and 20 mg spironolactone per day)on the basis of the above medications.The treatment was continued for 1month.The basic data of all patients were collected.Then compare the changes of Color Doppler Echocardiography indicators within 24 hours after admission and a month after treatment between the two groups,as well as the changes of MDA,s ST2,and NT-pro BNP levels in blood before intervention therapy,5 days after treatment,and a month after treatment,then all data were summarized and analyzed.All data were analyzed using SPSS22.0 statistical software,and the difference was statistically significant with a P value<0.05.Results(1)There was no significant difference in baseline data between the two groups(P>0.05);(2)The LVEF of the patients in the treatment group was higher than that of the control group after a month of treatment,and the difference was statistically significant(P<0.05);After a month of treatment,the LVEF of patients increased in both groups compared with 24 hours after admission,and the difference was statistically significant(P<0.05).(3)The blood levels of MDA,s ST2 and NT-pro BNP in treatment group were lower than those in control group for 5 days after treatment,and the difference was statistically significant(P<0.05).After a month of treatment,the levels of MAD,s ST2 and NT-pro BNP in the treatment group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Early oral administration of low-dose furosemide and spironolactone in patients with acute anterior wall myocardial infarction underwent primary percutaneous coronary intervention can increase the patient’s recent LVEF,reduce the patient’s blood levels of MDA,s ST2,and NT-pro BNP,and have a cardioprotective effect. |
PDF Full Text Request