| The central nervous system injury and rehabilitation has become a burning issue to be solved in the life sciences.With the development of medical level and the medical means,the survival of patients with central nervous disease has been significantly increased,and the survival time has been greatly prolonged.However,the reconstruction of patients’ nerve function still has a long way to go.With the development of microelectronics and materials science,more and more scientists try to use implanted microelectronics chips to treat nervous system trauma.Professor Wang Zhigong,Lü Xiaoying and Gu Xiaosong have proposed “Micro Electronic Neural Bridge” for the first time in the world to treat nervous system trauma since2004.On the basis of their research,this paper attempts to design a front-end amplifier for implantable neural signal detection,which provides a new solution for the restoration and reconstruction of neural function.The electrical characteristics of neural signal are described in this paper.On this basis,four kinds of front-end amplifiers for implantable neural signal detection are given,which are the classic three operation instrumentation amplifier,the improved three operation instrumentation amplifier,the gain-boost inverter-based front-end amplifier and the current-reuse inverter-based front-end amplifier.The four designs all use 0.18-μm CMOS technology,and the supply voltage is ±0.9 V.According to the simulation results of the unit circuits and the front-end amplifiers,the comparison of the four designs are studied and analyzed.Based on the research of the former students,the parameters in the classical three op-amp instrumentation amplifier are adjusted,and the performance of the instrumentation amplifier is improved.The combination of resistance feedback and capacitance feedback is innovatively proposed in this paper,which improves the gain and common mode rejection ratio of the frontend amplifier.The gain-boost inverter-based front-end amplifier and the current-reuse inverterbased front-end amplifier are also proposed for the first time in this paper,so that the system can obtain better performance and meet the requirements.Among them,the power consumption of the current-reuse inverter-based front-end amplifier is 15.48 μW,the mid-band gain is 44.94 dB,the CMRR and the PSRR are much greater than 70 dB,which is a great progress compared with the previous work in the group.These four kinds of front-end amplifiers for implantable neural signal detection proposed in this paper have their own specific advantages and can amplify neural signals.More progress has been obtained in the study of the front-end amplifiers for implantable neural signal detection.In addition,this article hopes to serve as a trigger,and more people can work together to make further breakthroughs in MENB. |
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