| Objective: 1.To evaluate the iodine nutrition status of school-age children.2.To explore the relationship between saliva iodine concentration and basic information,iodine nutrition status,thyroid function and thyroid related diseases in children.3.To explore the possibility of saliva iodine in children’s iodine nutrition evaluation,and to provide scientific basis for the normal value of children’s saliva iodine concentration.Method: Using the method of random cluster sampling,school-age children were selected from three primary schools in Ningjin County,Dezhou City,Shandong Province.Saliva samples,urinary samples,blood samples,drinking water samples and thyroid function indexes were collected.To analyze the correlation between children’s saliva iodine concentration and related indexes,and the possibility of saliva iodine in children’s iodine nutrition evaluation.Results: 1.In this study,a total of 453 school-age children aged 8-13 years old from Ningjin County,Dezhou City,Shandong Province were investigated,including 238 boys(52.5%)and 215 girls(47.5%).The age,height,weight,BMI and BSA of male children were slightly higher than those of female children(P < 0.05).2.In children,the median of drinking water iodine concentration was 12.1(11.2,12.9)μg/L,spot urinary iodine concentration was 120.6(63.8,220.1)μg/L,24-hour urinary iodine concentration was 116.2(74.1,188.4)μg/L,saliva iodine concentration was 106.2(67.8,180.8)μg/L,serum total iodine concentration was 101.4(90.2,112.4)μg/L,serum non-protein bound iodine concentration was 47.9(41.9,55.7)μg/L.3.The median of Tvol of children was 3.8(3.0,4.5)m L,Tvol/BSA was 3.3(2.7,3.9)m L/m2,the rate of total goiter and the thyroid nodule was 6.2% and 25.7%.The level of FT3 was 6.2 ± 0.6 pmol/L,FT4 was 18.3 ± 2.0 pmol/L,TSH was 2.2(1.6,2.9)m IU/L.The abnormal rates of FT3,FT4 and TSH were 0.3%,0.3% and 3.6%,respectively.4.Saliva iodine concentration was positively correlated with drinking water iodine concentration,spot urinary concentration,24-hour urinary iodine concentration,24-hour urinary iodine excretion,iodine intake level,thyroid volume and thyroid volume corrected by BSA(P < 0.05).5.Using saliva iodine to diagnose iodine intake level deficiency,the area under ROC curve was 0.715(P < 0.001).The best cut-off value of saliva iodine concentration was 104.6 ug/L and Yoden’s index was 0.305.Using saliva iodine concentration to diagnose iodine intake level excess,the area under ROC curve was 0.723(P < 0.001).The best cut-off value of salivary iodine concentration was 325.0 μg/L and Yoden’ s index was 0.504.6.The consistency test of saliva iodine and iodine intake level showed that the Kappa value was 0.294.7.When the saliva iodine concentration was less than 104.6 μg/L,the odd ratio of spot urinary iodine concentration < 100 μg/L、24-hour urinary iodine concentration < 100 μg/L and iodine intake level deficiency in children was 1.90,2.72,3.91(P < 0.05).When the saliva iodine concentration was more than 325.0 μg/L,the odd ratio of spot urinary iodine concentration > 300 μg/L、24-hour urinary iodine concentration > 300 μg/L、iodine intake level excess and thyroid nodules rate in children was 4.68,15.87,17.33 and 3.33(P < 0.05).Conclusions: 1.Children were in a suitable state of iodine.2.Saliva iodine concentration was positively correlated with drinking water iodine concentration,spot urinary concentration,24-hour urinary iodine concentration,24-hour urinary iodine excretion,iodine intake level,thyroid volume and thyroid volume corrected by BSA.3.The cutoff values for the diagnosis of iodine deficiency and excess in children were 104.6 μg/L and 325.0 μg/L.When the saliva iodine concentration was less than 104.6 μg/L,the risk of spot urinary iodine concentration < 100 μg/L,24-hour urinary iodine concentration < 100 μg/L and iodine intake level deficiency in children was significantly higher than that in other children.When the salivary iodine concentration was more than 325.0 μg/L,the risk of spot urinary iodine concentration> 300 μg/L,24-hour urinary iodine concentration > 300 μg/L,iodine intake level excess and thyroid nodules rate in children were significantly higher than those in other children.4.Saliva iodine concentration was consistent with iodine intake level.5.In this study,it is proved that saliva iodine level can be used as a reference index to evaluate children’s iodine nutrition status,but further verification is needed. |
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