Study On The Syndrome Characteristics Of Blood Stasis Syndrome In TCM Literature Of Diabetic Kidney Disease Based On Literature Mining Technology

Objective To explore the TCM syndrome elements and disease location distribution of "blood stasis" related diabetic kidney disease(DKD),to explore the relationship among different stages,four diagnosis information,syndromes of DKD patients related to blood stasis.To predict the possible development trend of syndromes and provide scientific basis for TCM treatment of "blood stasis" related diabetic nephropathy in Chinese medicine.MethodsThe Chinese Knowledge Network(CNKI),Wanfang Data Service Platform and VIP Database(VIP)were used as sources of literature retrieval,and the TCM literatures of DKD clinical research related to "blood stasis" in the past 20 years were taken as the research objects.Through literature review,combined with modern math ematical statistics data mining methods such as factor analysis and Bayesian network,the four diagnostic information and syndromes of "blood stasis" related diabetic nephropathy patients reported in the TCM literature were collected,sorted,and analyzed statistically.1 Using SPSS 22.0 and Microsoft Excel worksheets to analyze the frequency of basic information TCM literature on "blood stasis" related DKD and information of four diagnosis and syndrome of "blood stasis" related DKD.2 Using factor analysis technology in SPSS Modeler 15.0 software to study possible syndrome elements of DKD patients with “blood stasis”,and further verifying the accuracy of statistical analysis results of SPSS 22.0 and Microsoft Excel worksheets.3 Using the Bayesian network technology in SPSS Modeler 15.0 software to study the relationship among the stage of DKD patients related to "blood stasis",the four diagnosis information and the syndromes predicting the possible development trend of the syndromes and verifying the accuracy of statistical results in the literature review.Finally,Syndrome characteristics of blood stasis syndrome was obtained.Results1 General data analysis resultsA total of 164 articles were included in this study,involving a total of 10499 cases.From the time axis: the literature on DKD related to blood stasis in the past 20 years has been from 1 in 2000 to 10 in 2019,and the cases involved have ranged from 40 cases to 2033 cases,it can be seen that the number of patients with diabetic nephropathy is increasing year by year.There are mainly two types of literature,namely academic journals and master’s thesis.The early stages accounted for the largest proportion in the stage distribution of "blood stasis" related diabetic nephropathy patients(118 articles are involved,with a cumulative frequency of66.95%),followed by the clinical period(58 articles are involved,with a cumulative frequency of 24.62%),and the terminal stage(7 articles is involved,with a cumulative frequency of 0.58%)is the least.2 Analysis results of the four TCM information2.1 Symptom analysis resultsThe top 10 overall symptoms of “blood stasis” related diabetic nephropathy patients are: fatigue,numbness of limbs,lack of breath,soreness of waist and knees,dark lips,dry of mouth and pharyngeal,edema,five upset fever,frequent urination and Stinging.In which the top 10 symptoms in the early stages are: fatigue,numbness of the limbs,lack of breath,waist and knee soreness,dark lips,dry of mouth and pharyngeal,five upset fever,blood stasis,thirst.The first 10 symptoms in the clinical phase are: fatigue,numbness of the limbs,lack of breath,waist and knee soreness,edema,dark lips,frequent urination,tingling,and five upset fevers.The top 10 symptoms in the end stage are: numbness of the limbs,dark lips,e dema,fatigue,fatigue of the waist and knees,chills cold,frequent urination,black complexion,abdominal distension,lack of breath.The results showed that with the progression of DKD,the proportion of qi deficiency and yin deficiency symptoms such as fatigue,five upsets and fever was significantly reduced,while the proportion of yang deficiency,blood stasis and water dampness symptoms such as cold chills,limb numbnessand edema significantly increased.2.2 Tongue image analysis resultsThe tongue image of patients with "blood stasis" related diabetic nephropathy is generally dim tongue and thin white tongue fur.The first 7 tongue images in the early stages are: dark tongue,dark red tongue,thin white tongue,large tongue,toothed tongue,moss white and greasy,moss thin and yellow.The first 7 tongue images in the clinical stages are: pale tongue,fat tongue,thin white fur,tooth tongue,dark red tongue,white greasy fur,thick greasy fur.The top 7 Tongue images in the end-stages are: faint tongue,fat tongue,dental tongue,thick thick fur,white greasy fur,dark red tongue,thin white fur,there are dark tongue,fat tongue.As the diabetic nephropathy progresses,the proportion of blood stasis and water-wet tongue elephants such as tooth marks and thick greasy moss gradually increased.2.3 Pulse analysis resultsA total of 21 different pulses appeared in the 164 "blood stasis" related diabetic nephropathy patients included in this subject.These 21 different pulses are all composed of 7 basic pulses,which appear individually or in combination.Among them,the first 7 pulses in early stages are as follows: fine astringency,fine number,Shen thin,Shen astringent,string thin,thin string Fine,String,Fine.the first seven pulses in the clinal stage are: Fine,Shen Shen,Fine String,Fine Number,String,Shen,Thin.The first seven pulses at the end of the period are as follows:Thinness,Shenxiong,Strings,Slender Numbers,Strings,Shenzhen,Slender.There are basic pulses that are mainly thin pulses and compound pulses that are most thin,but the overall dominated by composite pulse.It can be inferred that DKD has complex and intractable characteristics3 Factor analysis methods found,taking the different stages of DKD patients related to "blood stasis" as an axis,the horizontal study found that the syndrome elements of different stages of DKD are different: the syndromes of early stage DKD patients with "blood stasis" are mainly qi deficiency,yin deficiency and blood stasis.Kidney is the most important factor,followed by liver and spleen.The clini cal symptoms of patients with DKD related to "blood stasis" are mainly yang deficiency,followed by qi deficiency,yin deficiency,blood stasis and wetness are the least.The syndromes of patients with end-stage DKD related to "blood stasis" are mainly yin de ficiency and yang deficiency,followed by qi deficiency and blood stasis,and the disease position is mainly spleen and kidney.It can be inferred that the syndrome evolution of DKD patients with "blood stasis" is qi deficiency,yin deficiency → yang deficiency → yin and yang deficiency.4 Bayesian network technology research has found that the syndromes of early patients with DKD related to "blood stasis" may be the most common syndrome of qi and yin deficiency and blood stasis syndrome.The syndromes of patients with DKD related to DKD clinical stage may be the most common spleen and kidney yang deficiency and blood stasis syndrome.Syndromes of end-stage DKD patients related to "blood stasis" may be the most common syndromes of yin and yang deficiency and blood stasis syndrome.The possible development trend of the predictive syndromes is:qi and yin deficiency syndrome → spleen and kidney yang deficiency syndrome →yin and yang deficiency syndrome.The blood stasis syndrome continues throughout the course of the disease and gradually increases as the disease progresses.Conclusion1 Blood stasis,qi deficiency,yin deficiency and water wetness throughout the course of the disease.As the disease progresses,qi deficiency is gradually reduced,and blood stasis and water-dampness syndrome are gradually increased.2 The possible development trend of TCM syndromes in patients with DKD related to "blood stasis" is as follows: deficiency of qi and yin,spleen and kidney yang deficiency syndrome,and deficiency of yin and yang.