The Clinical Observation Of Huqi Tongye Prescription Combined With Chemotherapy In The Treatment Of Advanced Esophageal Cancer With Syndrome Of Yin Deficiency And Phlegm Stasis

Objective:To observe the clinical efficacy of Huqi Tongye prescription combined with TP/TN regimen and simple TP/TN regimen in treating stage IIIB-IV of esophageal cancer with syndrome of yin deficiency and phlegm stasis,and provide basis for the clinical application of Huqi Tongye prescription.Methods:This study divided the qualified patients of the Oncology Department of Henan Hospital of Traditional Chinese Medicine and the Integrative Medicine Department of Henan Tumor Hospital from January 2019 to December 2019 into the treatment group and the control group according to the random method,and each group included 34 cases.The treatment group adopted Huqi Tongye prescription combined with TP/TN regimen,while the control group adopted simple TP/TN regimen.The observation was continued for 4 cycles.The main observation indicators of this study were short-term efficacy,TCM syndrome score and physical condition score(Karnofsky,KPS);the secondary observation indicators were tumor markers(CEA,SCC)and side effects.Results:1.Comparison of the short-term efficacy of the two groups:the short-term efficacy of the two groups of patients before and after treatment has been tested and has no statistical significance(p>0.05);the effcient and control rate of the treatment group were 47.1% and 85.3%,and the control group was 38.2% and 82.4%,the difference between the data of two groups was not statistically significant(p>0.05).2.Comparison of TCM syndrome scores between the two groups:after treatment,the total points of TCM syndromes in the treatment group and the control group have decreased,the reduction in the treatment group was more significant,and the difference between the two groups was significant(p<0.01);after treatment,the symptoms of the two groups were compared,the treatment group had outstanding effects in improving dry mouth and throat,five upset fever,constipation,and tongue coating,and the difference was statistically significant(p<0.05).3.Comparison of KPS scores between the two groups: the score of the treatment group after treatment was significantly higher than that before treatment,the difference was statistically significant(p<0.01);the score of the control group after treatment was a little higher than before,there was no statistical difference(p>0.05);the difference in KPS scores between the two groups after treatment was statistically significant(p<0.05).4.Comparison of tumor markers between the two groups:CEA:CEA concentration in the treatment group decreased after treatment compared with before treatment,and the control group also decreased compared with before,but there was no statistically significant difference in CEA concentration between the two groups after treatment(p>0.05).SCC:SCC concentration of the treatment group decreased after treatment compared with that before treatment,while SCC concentration of the control group increased slightly after treatmentand,there was no statistically significant difference in SCC concentration between the two groups after treatment(p>0.05).5.Comparison of toxic and side effects between the two groups:the incidence of gastrointestinal reaction and peripheral nerve toxicity in the treatment group was lower than that in the control group,the difference was statistically significant(p<0.05);while compared with the control group,there was no statistical difference between the treatment group’s leukopenia,thrombocytopenia,liver and kidney function damage,and hair loss reaction(p>0.05).Conclusion:1.Huqi Tongye prescription combined with TP/TN regimen in treating stage IIIB-IV of esophageal cancer with syndrome of yin deficiency and phlegm stasis has significant advantages compared with the simple TP/TN regimen in reducing patients’ TCM syndrome scores and improving KPS score,it shows that Huqitong Tongye prescription can improve the clinical symptoms of traditional Chinese medicine and improve the patient’s quality of life.2.Huqi Tongye prescription can reduce gastrointestinal reactions and peripheral neurotoxicity caused by chemotherapy.It is worthy of clinical application.