Clinical Significance Of Lung Cancer Related Tumor Markers In The Progression Of Lung Cancer After Chemotherapy

Objective: Through retrospective analysis,to explore the relationship between serum tumor markers and the progression,prognosis and pathological classification of lung cancer after chemotherapy,as well as how to select suitable tumor markers as the reference indicators to evaluate the progression of lung cancer after treatment for different histopathological types of lung cancer,to increase the accuracy of efficacy evaluation,and to provide reference for the clinical monitoring of lung cancer.Materials and methods: From January 2017 to December 2019,150 lung cancer patients from Affiliated Hospital of Guilin Medical College were collected,including age,gender,smoking history,pathological type,TNM stage and eight serum tumor markers.Use Spss22.0 statistical software to analyze the correlation between eight serum tumor markers and the progression,pathological types and prognosis of lung cancer patients.Results: 1.Among 150 lung cancer patients,72 were squamous cell carcinoma,44 were adenocarcinoma,34 were small cell lung cancer.This study showed that the changes of tumor markers in serum after progress of disease were different among different pathological types of lung cancer.The levels of CEA,NSE,SCCA,CYFRA21-1 and CA125 in patients with squamous cell carcinoma were significantly higher than those before progression,(P<0.05),Serum NSE,SCCA,Pro GRP,CA199 and CA125 levels did not change significantly before and after the disease progression.Serum CEA,CYFRA21-1 and CA153 levels were significantly higher in patients with adenocarcinoma than those before progression(P < 0.05),Serum NSE,SCCA,Pro GRP,CA199 and CA125 levels did not change significantly before and after the disease progression.The levels of NSE,Pro GRP,CEA and CYFRA21-1 in the serum of patients with small cell lung cancer were significantly higher than those before progression(P < 0.05),Serum CA125,CA199,CA153 and SCCA levels did not change significantly before and after the disease progression.2.Single factor survival analysis showed that the PFS of female patients was longer than that of male patients(P = 0.011),and that of patients without smoking history was longer than that of patients with smoking history(P = 0.008),suggesting that gender and smoking history were the factors influencing the prognosis of lung cancer patients.Age and pathological type did not show statistical significance.Multivariate survival analysis showed that smoking history was an independent prognostic factor for lung cancer patients(P = 0.021).3.The levels of SCCA and CYFRA21-1 in squamous cell carcinoma group were significantly higher than those in adenocarcinoma group and small cell lung cancer group(P < 0.05).The serum CA153 level in adenocarcinoma group was significantly higher than that in squamous cell carcinoma group and small cell lung cancer group(P < 0.05).The serum NSE and Pro GRP levels in small cell lung cancer group were significantly higher than those in squamous cell carcinoma group and adenocarcinoma group(P < 0.05).The serum CEA level of adenocarcinoma group was higher than that of squamous cell carcinoma group(P < 0.05),and there was no significant difference between adenocarcinoma group and small cell carcinoma group.Conclusions:1.Serum tumor markers can be used as a reference index to evaluate the progress of lung cancer after chemotherapy,serum CEA,NSE,SCCA,CYFRA21-1 and CA125 levels can be monitored in patients with squamous cell carcinoma,serum CEA,CYFRA21-1 and CA153 levels can be monitored in patients with adenocarcinoma,serum NSE,Pro GRP,CEA and CYFRA21-1 levels can be monitored in patients with small cell lung cancer.2.Smoking history is an independent prognostic factor in lung cancer patients.3.Serum SCCA and CYFRA21-1 levels were correlated with squamous cell carcinoma,CEA and CA153 levels with adenocarcinoma,NSE and Pro GRP levels with small cell lung cancer,serum levels of SCCA,CYFRA21-1,NSE,Pro GRP,CEA and CA153 are related to the pathological types of lung cancer,which can be used as a reference index to distinguish the pathological types of lung cancer.