The Correlation Analysis Of Therapeutic Effect And Predictive Index Of Huazhuoxiaozheng Decoction Combined With Western Medicine In The Treatment Of Undamaged Tubal Pregnancy

Objective:To observe the effect of huazhuoxiaozheng decoction combined with western medicine in the treatment of undamaged tubal pregnancy,and to analyze the correlation between serum β-h CG,progesterone,the maximum diameter of the mass,and the maximum depth of pelvic effusion,so as to provide the basis for predicting the effect of conservative treatment.Methords:From January 2017 to December 2019,90 patients who were selected from the gynecological inpatients in Hebei Hospital of traditional Chinese medicine and met the inclusion criteria were randomly divided into the observation group and the control group,45 in each group.The observation group was treated with methotrexate intramuscular injection and mifepristone tablets combined with huazhuoxiaozheng decoction,and the control group was treated with methotrexate intramuscular injection and mifepristone tablets.On the 7th day of treatment,the serum β-h CG quantity was checked,if the decrease was less than 15%,it proved that the treatment was invalid,the blood routine examination,liver and kidney function were normal,and the drug could be used repeatedly.A total of 14 days were observed,and the clinical efficacy,laboratory examination,TCM syndrome score of the two groups were compared.Binary logistic regression analysis was used to analyze the correlation between the prediction indexes and the treatment effect in the observation group,and to preliminarily determine the risk factors with predictive value for the conservative treatment effect.Result: 3 cases fell off in the observation group,2 cases fell off in the control group and 85 cases were involved in the analysis of results.1 Before treatmentThere was no significant difference in age,history of pregnancy and childbirth,time of menopause,serum β-h CG,progesterone,maximum diameter of mass,maximum depth of pelvic effusion and TCM syndrome score between the two groups(P>0.05).2 After treatment2.1 Clinical efficacy: the effective rate of the observation group was85.7%,and that of the control group was 81.4%,the difference was statistically significant(P<0.05).2.2 Curative effect of TCM syndrome: the effective rate of the observation group was 88.1%,and that of the control group was 81.4%,the difference was statistically significant(P<0.05).2.3 Group: there were statistically significant differences in serum β-h CG,maximum diameter line of mass and maximum depth of pelvic effusion before and on the 7th day of treatment(P<0.05).There were statistically significant differences in serum β-h CG,progesterone,maximum diameter of mass,maximum depth of pelvic effusion and TCM syndrome score before and on the 14 th day(P<0.05).2.4 Between groups: on the 7th day of treatment,the differences of the two groups in serum β-h CG and the maximum diameter of the mass were statistically significant(P<0.05);the difference of the maximum depth of pelvic effusion was not statistically significant(P>0.05).There were significant differences between the two groups in serum β-h CG,progesterone,maximum diameter line of mass,maximum depth of pelvic effusion and TCM syndrome score on the 14 th day of treatment(P<0.05).3 Binary logistic regression: the initial serum β-h CG and progesterone were significantly correlated with the therapeutic effect(P<0.05);the maximum diameter of the initial mass and the maximum depth of the initial pelvic effusion were not significantly correlated with the therapeutic effect(P>0.05).4 Safety index: there were no significant abnormalities in vital signs,ECG,blood routine,liver and kidney function,coagulation during the treatment in the two groups,and there was no significant difference in the incidence of adverse reactions and the addition of methotrexate and mifepristone tablets(P>0.05).Conclusion:1.Huazhuoxiaozheng decoction combined with methotrexate and mifepristone tablets can improve the clinical effect,effectively improve the clinical symptoms and TCM syndromes,and provide a new theory and method for the drug conservative treatment of undamaged tubal pregnancy.2.The initial serum β-h CG and progesterone are the risk factors that influence the effect of conservative treatment of undamaged tubal pregnancy.