The Performance Of IVIM Model Combined With DWI On Evaluating The Efficacy Of Treatment For Lung Cancer

Objective:To investigate the value of intravoxel incoherent motion(IVIM)combined with diffusion weighted imaging(DWI)in evaluating the efficacy of treatment for lung cancer.Materials and Methods:From February,2016 to February,2019,58 patients with advanced NSCLC who received platinum-based standard first-line chemotherapy.CT and MRI examination were performed before treatment,and CT Reexamination was performed 2 cycles after chemotherapy.According to RECIST1.1 standard,the patients were divided into effective group and ineffective group.ADC,D,Dp,f,DDC and a were measured.The tumor regression rate was calculated.Pearson correlation analysis was used to study the correlation between 6 parameters of tumor regression rate.Receiver operating characteristic(ROC)curve was used to evaluate the predictive power of parameters with statistical significance.Results The tumor regression rate was negatively correlated with ADC value and D value[r=-0.264,P=0.045;r=-0.314,P=0.016].The ADC value and D value of the effective group were lower than ineffective group,and there was significant difference between the two groups(P<0.05),and the other parameters had no significant difference between the two groups(P>0.05);The area under the ROC curve of D value and ADC value were 0.835 and 0.824 respectively,the sensitivity was 89.5%vs 71.1%,and the specificity was 65%vs 85%.Conclusion The parameters D and ADC,derived from IVIM and DWI,potentially indicate a valuable measure of the evaluation of curative effect of lung cancer.These results are expected to provide more imaging evidences for individualized treatment of advanced NSCLC.