Analysis Of Prognostic Factors For Recurrence And Metastasis Of Non-small Cell Lung Cancer After Radical Surgery

Objective:Primary lung cancer is considered to be one of the highest cancer incidence rate in the world.Despite its breakthrough in diagnosis and treatment,lung cancer is still the leading cause of cancer related death worldwide.Surgical resection provides the best chance to cure early non-small cell lung cancer(NSCLC).However,recurrence is still common in NSCLC patients who have undergone radical resection but complete resection,and it is a major obstacle to long-term survival of patients with this disease.In this study,we analyzed the recurrence and metastasis of stage Ⅰ-Ⅲ a non-small cell lung cancer,and explored the risk factors of recurrence and metastasis.So as to achieve early detection,early intervention,try to extend the life of patients.Methods:201 patients with non-small cell lung cancer were retrospectively analyzed Cox univariate analysis was performed on 13 variables including age,gender,smoking history,pleural involvement,clinical type,histological type,T stage,N stage,stage,operation method,operation site,number of lymph node dissection,and postoperative chemotherapy cycle.The variables with statistical significance(P<0.1)were found in univariate analysis,Cox regression proportional hazards model was used for multivariate analysis to determine the influencing factors of recurrence and metastasis.P≤0.05 was statistically significant.Results:Among 201 patients with lung cancer after radical operation,98cases had recurrence and metastasis.The 1-,2-,and 3-year disease-free survival rates were 83%,69%,and 51.3%,respectively.Univariate analysis showed that smoking history(P=0.06),clinical type(P=0.06),T stage(P=0.01),N stage(P<0.01),stage(P<0.01),and number of lymph node dissection(P<0.01)were risk factors for recurrence and metastasis.In multivariate regression analysis,stage(P=0.04),surgical site(P=0.08)and number of lymph node dissection(P<0.1)were independent prognostic factors for postoperative recurrence and metastasis.Conclusion(s):1.T stage,N stage,smoking,clinical type and were the influencing factors of recurrence after radical resection of lung cancer.2.Tumor stage and number of lymph node dissection were independent prognostic factors for recurrence of lung cancer after radical resection.