Breast Cancer Amplification Sequence(BCAS1)Regulates Human Left Brain Cognitive Network Computing

In this paper,brain breast cancer amplification sequence(BCAS1)feedback/upstream/downstream activation and inhibition molecular knowledge network was constructed in human left brain,which is closely related to human left brain cognition.By integrating GRNInfer and DAVID,based on the common knowledge of feedback/upstream/downstream activation and inhibition of different molecules of BCAS1,we proposed and verified new hypotheses what BCAS1 regulates the cognitive mechanism of human left brain.The multiple subnets are as follows:Integrating BCAS1 upstream activation and downstream activation of cancer pathway,this paper proposes and verifies that BCAS1 cancer pathway induces human left brain cognition,through its upstream activation of endocrine and central nervous system | extracellular space |sphingolipid signal transduction pathway | cell movement | adhesion spot exists in ZFP36L2,DDIT4,LGALS3BP subnetwork;and downstream activation β Catenin binding | negative regulation of neuroblast proliferation | gap junction assembly | axon regeneration | intercellular adhesion signal transduction | actin cytoskeleton in HSPA2,AF016004 subnets.(1)Bcas1 positive self feedback activates cancer pathway through endocrine and central nervous system | extracellular space | sphingolipid signal transduction pathway | cell movement | focal adhesion| β Catenin binding | negative regulation of neuroblast proliferation | gap junction assembly | axon regeneration | intercellular adhesion signal transduction |actin cytoskeleton affects cognition and positive verification.(2)Bcasl positive self feedback inhibited protein kinase activity;Its feedback and downstream inhibitory protein serine/threonine kinase activity;Its feedback and downstream inhibit peptide serine phosphorylation;Its upstream and downstream inhibit brain development;Its upstream and feedback inhibition of cell cycle was verified in a negative direction.(3)Through the activation or inhibition network of bcasl’s different negative self feedback,we proposed that bcas1 speed limited MAPK,vascular endothelial growth factor receptor,FC ε Receptor and small GTPase mediated signal transduction,positive and negative regulation of apoptosis,platelet activation,regulation of DNA templated transcription,protein kinase,unfolded protein and ATP binding,structural molecular activity,endocytosis,and cytoplasmic negative verification.In conclusion,this paper proposes and verifies the new system mechanism of bcasl affecting cognition.The new system analysis has added new content to the cognitive theory and application of human left brain,and provides an important theoretical basis and has application value for the research of cognitive mechanism of human left brain.