Expression Of USP22 And C-myc In Nasopharyngeal Carcinoma Tissues And Its Relationship With Clinical Prognosis

Objective: Previous studies have shown that ubiquitin specific peptidase 22(USP22)protein highly expressed in human lung,kidney,stomach,thyroid and other cancers.Studies have confirmed that USP22 is related to the transcription process mediated by C-myc in mammalian cells.The USP22 gene can activate the transcription of C-myc and regulate the expression of downstream genes.USP22 and C-myc regulate the cell cycle together.However,there have been no reports on the combined detection of USP22 and c-myc in nasopharyngeal carcinoma tissues in domestic literatures.This study aims to detect the expression of USP22 and C-myc in NPC and investigate the relationship with clinicopathological factors and prognosis.Methods: 82 cases of NPC(the case group)were diagnosed by department of pathology of Guilin Medical University Affiliated Hospital from June 2013 to December 2014.20 cases of nasopharyngitis were randomly collected as control group.The expressions of USP22 and C-myc of all cases tissues were detected by Immunohistochemistry.The expression correlation of USP22 and C-myc,clinicopathologic features and prognosis were analyzed by statistical methods.Results:(1)The positive expression rates of USP22 and C-myc in NPC were significantly higher than those in nasopharyngitis tissues(57.32% and 92.68% VS 10% and 0%,P<0.01).(2)The positive expression rates of USP22 and C-myc were significantly associated with lymph node metastasis(P<0.05),but not significantly associated with age,sex and histological grade(P>0.05).(3)The expressions of USP22 and C-myc in NPC tissues were positively correlated(P<0.05).(4)The positive USP22 expression group of 3-year overall survival(OS)and progression-free survival(PFS)were shorter than negative expression group(P < 0.05).Conclusion(s):(1)The increased expressions of USP22 and C-myc in NPC are associated with lymph node metastasis,and both have synergistic effects.(2)The prognosis of nasopharyngeal carcinoma patients with positive expression of USP22 is worse than those with negative expression.(3)Detecting the expression of USP22 is conducive to prognosis judgment of nasopharyngeal carcinoma,USP22 is expected to be a therapeutic target for NPC.