Correlation Analysis Between Chinese Medicine Syndrome Types And Metabolic Indicators In Metabolic Syndrome And 25(OH)D3 Levels

Objective:To analyze the distribution rule of Chinese medicine syndrome types and the correlation between 25(OH)D3 levels and Chinese medicine syndromes in patients with metabolic syndrome,and to provide new ideas for clinical diagnosis and treatment of metabolic syndrome.Methods:A total of 180 patients who were hospitalized in the Department of Endocrinology of the Affiliated Hospital of Nanjing University of Chinese Medicine and met the inclusion and exclusion criteria,were enrolled.Among them,152 patients who met the diagnosis of metabolic syndrome were the observation group(MS group),and 28 patients with non-metabolic syndrome were the control group(NMS group).A cross-sectional study was conducted by filling out a"Case Observation Form",in which clinical data was filled out by the investigator after reviewing the patients’ current hospitalization information,while medical history and symptoms were objectively filled out by the investigator after interviewing the patients face-to-face,and four diagnostic information was filled out by at least two deputy director or more advanced Chinese medical physicians after diagnosis.The information was input into a database and analyzed using statistical methods.Patients in MS group were analyzed using factor analysis for Chinese medicine syndrome types,correlation analysis for Chinese medicine syndrome types and 25(OH)D3 levels.The clinical data in MS and NMS groups were compared and analyzed generally.With using trichotomous grouping for 25(OH)D3 levels,intergroup analysis for metabolic indicators,and ordered multicategorical Logistic regression analysis,the risk factors associated with 25(OH)D3 levels were obtained.Results:1.Four diagnostic information of Chinese medicine:Based on the results of factor analysis and clinical syndrome differentiation of professional Chinese medicine physicians,combined with the theoretical knowledge of Chinese medicine,the 152 cases of MS group were analyzed for syndrome differentiation,and finally four Chinese medicine syndrome types were obtained.They were:41 cases(26.97%)with phlegm obstruction;42 cases(27.63%)with Qi and Yin deficiency;37 cases(24.34%)with binding of phlegm and stasis;and 32 cases(21.05%)with Yin deficiency and exuberant heat.2.Study on 25(OH)D3 levels and Chinese medicine syndrome types of metabolic syndrome:the highest level of 25(OH)D3 was found in patients with phlegm obstruction.The simple correlation between Chinese medicine syndrome types and 25(OH)D3 levels was analyzed by pearson correlation analysis,which yielded Pearson r value(-0.064),P value(0.432),and there was no significant correlation between the two groups(P>0.05).3.Clinical data related to MS group and NMS group were found to be statistically significant by analysis of body mass index(BMI),waist circumference(WC),systolic pressure(SBP),triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-Density Lipoprotein Cholesterol(LDL-C),fasting blood glucose(FPG),glycosylated hemoglobin(HbA1c),insulin resistance index(IR),fasting insulin(FINS),serum bicarbonate(HCO3),lipoprotein(LP(a)),glycosylated serum protein(GSP),and serum nitric oxide between groups.The 25(OH)D3 levels of patients in NMS group were significantly higher than in the MS group.4.The 25(OH)D3 levels of patients in the MS group were divided into three groups,and the correlation analysis showed that TC,LDL-C,age,TG,FPG,HbAlc,HOMA-IR,and fasting INS were negatively correlated.The results of ordered multicategorical logistic regression analysis showed that age and TC had an effect on 25(OH)D3 levels in patients in the MS group,and age was a risk factor(OR=1.060,P=0.000),and TC was also a risk factor(OR=1.523,P=0.041).Conclusion:The Chinese medicine syndrome types of MS group were discriminated as:phlegm obstruction,qi and yin deficiency,binding of phlegm and stasis,and yin deficiency and exuberant heat.There was no significant correlation between different Chinese medicine syndrome types and 25(OH)D3 levels.Patients with metabolic syndrome had lower 25(OH)D3 levels than patients without metabolic syndrome and increasing age and elevated total cholesterol levels were both risk factors for low 25(OH)D3 levels.