Case Analysis And Curative Effect Observation Of DaHuangZheChong Pills And GuiZhi FuLing Ointment On Treating Chronic Atopic Dermatitis

ObjectivesThe aim of this research is to study the clinical curative effects and safety of DaHuangZheChong Pills and GuiZhi FuLing ointment on treating Chronic Atopic Dermatitis,thus providing an effective acupuncture treatment conducive to the promotion.MethodsThis research adopts the prospective randomized controlled study.A total of 36 patients from the dermatology out-patient clinic and ward of Guangdong Provincial Hospital of Traditional Chinese Medicine were enrolled in the study.Patients were divided randomly into treatment group(DaHuangZheChong Pills and GuiZhi FuLing ointment)and control group(DaHuangZheChong Pills and GanCao ointment),Treatment time is within 4 weeks.SCOR AD scores and the scale of TCM symptoms curative effect index were observed and recorded.Results1.After treatment of 1,2 weeks,the difference of SCORAD scores have no statistical significance(P>0.05),but after 4 weeks treatment its SCORAD scores have statistical significance(P<0.05).2.After treatment of 1,2 weeks,the difference of lichenification and dryness(unaffected skin)scores have no statistical significance(P>0.05),but after 4 weeks treatment its SCORAD scores have statistical significance(P<0.05).3.After treatment of 1 weeks,the difference of itching and sleep-affecting degree scores have no statistical significance(P>0.05),but after2 and 4 weeks treatment its SCORAD scores have statistical significance(P<0.05).4.After treatment of 1,2,4weeks,the difference of the scale of TCM symptoms curative effect index have no statistical significance(P>0.05).5.For treatment and control group’s intra-groupcomparison,the comparisons between the 4 weeks after treatment with before the treatment all have statistical significance(P<0.05).6.Two patients in the treatment group and the control group each reported an increase in the number of stools after taking the DaHuangZheChong Pills.There were no adverse reactions reported for external use of GuiZhi FuLing ointment and licorice ointment.7.Follow-up after 2 weeks,1 person in the treatment group had skin lesions recurrence,the recurrence rate was 5.6%,and 2 people in the control group had skin lesions recurrence,the recurrence rate was 11.1%,the difference was not statistically significant(P>0.05).Conclusion1.The treatments of both treatment group and control group had therapeutic effect.2.In terms of SCORAD scores’improvement and efficacy judgment,the treatment group had better therapeutic effect,especially in the four weeks after the treatment.3.Both two groups have a certain therapeutic effect on lichenification of skin lesions and dry skin.The curative effect of the treatment group was better than that of the control group,especially after 4 weeks of treatment.4.Both two groups have a certain therapeutic effect on relieving itching and insomnia caused by itching.The effect of the treatment group is better than that of the control group,especially after 2 weeks of treatment.5.The curative effect of TCM symptoms was similar between the two groups.6.There was no serious side effect reported and the therapeutic Safety is proved as well as the recurrence rate is in low level.