High-risk Factors Of Early Coagulation Abnormality In Premature Infants And Their Correlation With Intraventricular Hemorrhage

Under physiological conditions,the human blood coagulation system is a very complex dynamic balance system,a dynamic process of gradual development and maturity.During the newborn period,especially in premature infants,blood coagulates due to the imperfect development of internal organs and systems The factor concentration is relatively low,and any part of the process will be dysfunctional or abnormal,and the entire coagulation system will be out of balance,especially when certain diseases affect the coagulation function of pregnant women and newborns.This may lead to intraventricular hemorrhage in premature infants,causing a series of long-term clinical effects,such as language impairment,epilepsy,mental retardation,cerebral palsy,vision and hearing loss,and other neurological sequelae.This study aims to explore the high-risk factors of abnormal coagulation function in premature infants and their correlation with intraventricular hemorrhage,in order to provide new reference basis for early identification,early diagnosis,early treatment and early prevention.Objective:1.Analyze the related high-risk factors of early coagulation abnormality in premature infants.2.To explore the relationship between intraventricular hemorrhage and early coagulation abnormalities in premature infants.Methods:1.The study subjects:Select 322 premature infants who were born in the Foshan Maternal and Child Health Hospital affiliated to Southern Medical University from January 1,2019 to January 31,2021 and were hospitalized in the neonatology department.238 cases will meet the inclusion and exclusion criteria as the research object,premature infants were collected and retrospectively analyzed clinical data such as high-risk factors in the perinatal period,basic birth data,blood coagulation related indicators and intraventricular hemorrhage.2.Research methods:The study subjects were divided into groups based on the results of coagulation function,respectively,the abnormal coagulation function group and the normal group.Statistical analysis was carried out by SPSS26.0 software.The measurement data was expressed by the mean(χ)±standard deviation(s),and the t test was used.For comparison,the count data is represented by frequency and percentage,and the chi-square test is used for comparison.First,the high-risk factors for abnormal blood coagulation in preterm infants were screened out by univariate analysis,and then the high-risk factors with statistical differences(P<0.05)in the above analysis were included in the binary logistic regression model for multivariate analysis.Independent risk factors for statistical differences(P<0.05).The chi-square test and t test were used to calculate the statistical difference between the coagulation function indexes of preterm infants and intraventricular hemorrhage((P<0.05).Result:1.A total of 238 preterm infants were included in this study,including 44 cases in the normal blood coagulation function group and 194 cases in the abnormal blood coagulation function group.2.The results of single factor analysis showed that:multiple pregnancy,parity,hypoxic asphyxia,umbilical cord around the neck,premature rupture of membranes and early coagulation abnormalities in premature infants were statistically different(P<0.05).3.The results of multivariate analysis showed that:multiple pregnancy(OR=3.123,95%CI=1.179～8.277);hypoxic asphyxia(OR=3.618,95%CI=1.467～8.925);umbilical cord around the neck(OR=3.114,95%CI=1.043～9.293);premature rupture of membranes(OR=3.062,95%CI=1.203～7.794)and other factors can increase the risk of early coagulation abnormalities in preterm infants,and they are all positively correlated.4.There is a statistical difference between intraventricular hemorrhage in preterm infants and abnormal coagulation function in the early postnatal period(P<0.05).5.The early plasma prothrombin time(PT)of premature infants with intraventricular hemorrhage is abnormal.Conclusion:1.Multiple pregnancy,hypoxic asphyxia,umbilical cord around the neck,and premature rupture of membranes are independent risk factors for abnormal blood coagulation in the early postnatal period of preterm infants.2.There may be a correlation between intraventricular hemorrhage in premature infants and abnormal coagulation function in the early stage.3.Abnormal plasma prothrombin time(PT)in early preterm infants has a suggestive significance for intraventricular hemorrhage.