| Objective:1.Discuss the method of classification of Chinese medicine formulas,and with a view to provide reference for the research of formulas classification.2.By building a mathematical model,we can calculate the similarity coefficients of each analogous formula and San’ao decoction in terms of herb composition,the core herb proportions,and the terms of the overall dosage of the whole formula,we can compare the similarity between San’ao decoction’s analogous and San’ao decoction,and with a view to provide reference and new idea for the research of analogous formulas.3.Collect the formulas containing "Ephedra" and "Almond",calculate the similarity coefficients of these formulas and San’ao decoction in terms of herb composition,the core herb proportions,and the terms of the overall dosage of the whole formula.According to the calculation result to discover potential San’ao decoction’s analogous formulas.Methods:1.Collect and sort out the data of ancient Chinese medicine books,sort out the content of the theory of formula classification in various periods,and analyze the main method of formula classification.2.Collect and sort out the San’ao decoction’s analogous formulas clearly recorded in ancient Chinese medicine books,and compare the similarity between various formulas and San’ao decoction based on the result of Jaccard similarity coefficient of terms of herb composition,core herb proportion,cosine similarity of the overall dosage of the whole formula,and comprehensive similarity.3.Collect the formulas containing "Ephedra" and "Almonds",calculate the similarity with San’ao decoction based on the Jaccard similarity coefficient of terms of herb composition,core herb proportion,cosine similarity of the overall dosage of the whole formula,and comprehensive similarity,and discover the potential San’ao decoction’s analogous formulas based on the similarity.Results:1.Through combing the literature of traditional Chinese medicine in the past the classification methods of formulas have mainly formed the classification of disease pattern,the classification of etiology,the classification of viscera,the classification of clinical departments,the classification of treatment methods,the classification based on main formulas,the classification based on main herbs,the classification of dosage forms,and the general classification method,and so on.These methods of classification of formulas are classified from the diseases treated by the formulas,the structure of the formulas,and the functions of the formulas.The classification of disease pattern,the classification of etiology,the classification of viscera,the classification of clinical departments classify formulas from the perspective of the diseases treated by formula,among them,the classification of viscera is for the location of the disease,and the classification of etiology is for the cause of the disease,both supplement the deficiency of the classification of disease pattern,and make the classification more detailed,they are an extension of the classification of disease pattern;the classification based on main formulas and the classification based on main herbs classify formulas from the formula structures;the classification of treatment methods classifies formulas from their functions.2.A total of 21 San’ao decoction’s analogous formulas clearly recorded in ancient books of traditional Chinese medicine were collected,among them,19 formulas and San’ao decoction have a comprehensive similarity of ≥50%in drug composition and dosage,accounting for 90%of the 21 San’ao decoction’s analogous formulas;the Jaccard similarity coefficient of herb composition shows that in terms of herb composition,the most similar to San’ao decoction is Zhuihun decoction in San Yin Ji-Bing Zheng FangLun,followed by Siao decoction in Hai Ying Tong Cui and Jiajian San’ao decoction in Zheng Zhi Zhun Sheng,Jiajian San’ao Decoction in Lei Bian Zhu Shi Ji Yan Yi Fang,two Wuao decoction in Tan Liao Fang,etc.The similarity of the core herb proportions shows that in terms of the core herb proportion,the most similar to San’ao decoction is Zhuihun decoction in San Yin Ji-Bing Zheng FangLun,followed by Wuhu decoction in Zu Ji,Jiajian San’ao decoction in Zheng Zhi Zhun Sheng,San’ao decoction in Ma Zhen Chan Zhu,Jiawei San’ao decoction in Ma Ke Huo Ren Quan Shu,etc.The cosine similarity of the overall dosage of the whole formula shows that in terms of the overall dosage of the whole formula,the most similar to San’ao decoction is Siao decoction in Hai Ying Tong Cui,followed by Jiajian San’ao decoction in Yi Xue Ru Men,Jiawei San’ao decoction in Ma Ke Huo Ren Quan Shu,Wuhu decoction in Zu Ji,Zhui hun decoction in San Yin Ji-Bing Zheng Fang Lun,etc.The above three similarity coefficients and weight coefficients are distributed proportionally,and finally the comprehensive similarity is obtained.The results show that the most similar to San’ao decoction is Zhuihun decoction in San Yin Ji-Bing Zheng Fang Lun,followed by Siao decoction in Hai Ying Tong Cui and Jiajian San’ao decoction in Zheng Zhi Zhun Sheng,Wuhu decoction in Zu Ji,Jiawei San’ao decoction in Ma Ke Huo Ren Quan Shu,etc.Xinjia San’ao decoction in Popular Treatise on Febrile Diseases is the least similar to San’ao decoction.3.A total of 365 formulas containing "Ephedra" and "Almond" were collected.Jaccard similarity coefficient of herb composition shows that there are 4 formulas that are most similar to San’ao decoction in terms of herb composition.They are Huagai San in Bo Ji Fang,Mahuang decoction in Ru Men Shi Qin,Mahuang San and Sanhe decoction in Pu Ji Fang,they all have the similarity of 100%;there are 17 formulas with a similarity of 75%,43 formulas with a similarity of 70%to 60%,and 301 formulas with a similarity less than 60%;the similarity of the core herb proportions shows that there are 7 formulas that are most similar to San’ao decoction in terms of the core herb proportion,they are Erwu San in Wai Tai Mi Yao Fang quoted from Fan Wang Fang,Xingren decoction in Wai Tai Mi Yao Fang quoted from Bei Ji,Huagai San in Bo Ji Fang,Xingzi San in Quan Sheng Zhi Mi Fang,Mahuang decoction in Ru Men Shi Qin,Mahuang San and Sanhe decoction in Pu Ji Fang,they all have the similarity of 100%;there are 3 formulas with a similarity of 100%to 90%,4 formulas with a similarity of 90%to 80%,15 formulas with a similarity of 80%to 70%,23 formulas with a similarity of 70%to 60%,313 formulas with a similarity less than 60%;the cosine similarity shows of the overall dosage of the whole formula that there are 2 formulas that are most similar to San’ao decoction in the overall dosage of the whole formula,namely Mahuang decoction in Ru Men Shi Qin and Mahuang San in Pu Ji Fang,the similarity is both 100%;there are 4 formulas with a similarity of 100%to 90%,20 formulas with a similarity of 90%to 80%,46 formulas with a similarity of 80%to 70%,87 formulas with a similarity of 70%to 60%,217 formulas with a similarity less than 60%;the above 3 similarity coefficients and weight coefficients are distributed proportionally,and finally the comprehensive similarity is obtained,according to the golden ratio with a threshold of 50%,there are 136 formulas with higher similarity to San’ao decoction,among which the two formulas with the highest similarity are Mahuang decoction in Ru Men Shi Qin and Mahuang San in Pu Ji Fang,followed by Sanhe decoction in Pu Ji Fang,Huagai San in Bo Ji Fang,Mahuang San in Bei Ji Qian Jin Yao Fang,Mahuang decoction in You You Xin Shu quoted from Zhen Dou Lun,Mahuang Gancao decoction in Shang Han Zong Bing Lun,Xingzi San in Quan Sheng Zhi Mi Fang,Xingren decoction in Wai Tai Mi Yao quoted from Bei Ji,Sishun San in Yang Lao Feng Qin Shu,Kuandong pill in Sheng Ji Zong Lu,etc.Conclusion:1.The theory of the method of classification of Chinese medicine formulas had appeared in Qin and Han Dynasty,the maturity and perfection of its theory are closely related to the continuous development of TCM theory.The method of classification of Chinese medicine formulas all facilitate the understanding of theory,method,formula,and medicine system.The enrichment of the method of classification of Chinese medicine formulas has promoted the development of the theory and application of formula.2.The results of similarity coefficients shows that,in 21 San’ao decoction’s analogous formulas clearly recorded in ancient Chinese medicine books,19 formulas and San’ao decoction have a comprehensive similarity of ≥50%,therefore,to determine whether a formula belongs to the San’ao decoction’s analogous formulas class in terms of drug composition and dosage from objective mathematical indicators,its comprehensive similarity should not be less than 50%.Taking a small sample of the similarity study between San’ao decoction and San’ao decoction’s analogous formulas as an example,a mathematical model is established from the aspects of drug composition,core drug proportion,and overall dosage of the whole prescription,and it is feasible that the objective similarity coefficient obtained by calculation is used to compare the similarity between two formulas.3.The similarity algorithm results show that among the 365 formulas containing "Ephedra"and "Almond",there are 56 formulas with higher similarity to San’ao decoction;they are respectively Mahuang decoction in Ru Men Shi Qin,Mahuang San in PuJi Fang,Sanhe decoction in Pu Ji Fang,Huagai San in Bo Ji Fang,Mahuang San in Bei Ji Qian Jin Yao Fang,Mahuang decoction in You You Xin Shu quoted from Zhen Dou Lun,Mahuang Gancao decoction in Shang Han Zong Bing Lun,Xingzi San in Quan Sheng Zhi Mi Fang,etc.These formulas are the mined potential formulas for San’ao decoction.4.Through the Jaccard similarity coefficient of terms of herb composition,core herb proportion,cosine similarity of the overall dosage of the whole formula,and comprehensive similarity to compare two formulas is feasible.Objective indicators derived from this mathematical model can avoid human subjective factors and discover potential analogous formulas.It is of reference value for the research of analogous formulas. |
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