Effects Of Vitamin A And D Levels On Neurodevelopment In Infants With Brain Injury

Objective: to investigate the effects of vitamin A and vitamin D levels on neurodevelopment in infants with brain injury.Methods:the first people’s Hospital of Jining City was used as the baseline population.Methods: a total of 100 full-term children with brain injury were selected from June 2017 to June 2018 in our hospital.The basic information was investigated and followed up.The serum vitamin A and D levels were measured by electrochemiluminescence and high performance liquid chromatography respectively in March,June and December.The patients were divided into vitamin A deficiency group,vitamin D deficiency group,vitamin A and D deficiency group,and life support group The neurobehavioral development quotient(DQ)was measured.The correlation between the levels of vitamin A and D and the neurodevelopmental level of brain injury in children with vitamin A deficiency was compared The differences between vitamin A and vitamin D groups were compared.Results:a total of 100 children were followed up.After 3 months,6months and 12 months,the levels of vitamin AD were measured and divided into groups,and the neurobehavioral development quotient(DQ)of the children was measured.In March,the vitamin A deficiency group was 29%,the vitamin D deficiency group was 27%,the simultaneous vitamin AD deficiency group was 35%,and the normal vitamin AD group was 9%.In June,vitamin A deficiency group accounted for 30%,vitamin D deficiency group accounted for 32%,vitamin AD deficiency group accounted for 30%,and vitamin AD normal group accounted for 8%.In December,vitamin A deficiency group accounted for 34%,vitamin D deficiency group accounted for 32%,vitamin AD deficiency group accounted for 24%,and vitamin AD normal group accounted for 10%.T test showed that in March,compared with normal group,vitamin A deficiency group had t =-8.58,P < 0.05;vitamin D deficiency group compared with normal group,t =-8.391,P < 0.05;vitamin AD deficiency group compared with normal group,t =-8.855,P < 0.05;analysis of variance was used between vitamin A deficiency group and vitamin D deficiency group,P > 0.05.In June,the vitamin A deficiency group compared with the normal group,t =-7.7475,P < 0.05;the vitamin D deficiency group compared with the normal group,t =-8.322,P < 0.05;the vitamin AD deficiency group compared with the normal group,t =-9.062,P < 0.05;the vitamin A deficiency group and vitamin D deficiency group used variance analysis,P > 0.05.In December,compared with the normal group,the vitamin A deficiency group and the normal group,t =-11.066,P < 0.05;the vitamin D deficiency group compared with the normal group,t =-8.950,P < 0.05;compared with the normal group,t =-6.858,P < 0.05;the vitamin A deficiency group and vitamin D deficiency group were analyzed by variance analysis,P > 0.05.Comprehensive analysis of the vitamin A deficiency group,vitamin D deficiency group,vitamin AD deficiency group and normal group in March,June and December showed that vitamin AD was correlated with development quotient,that is to say,vitamin AD had an impact on the neurodevelopment of children with brain injury.There was no significant difference between vitamin A deficiency group and vitamin D deficiency group.Conclusions : there is a correlation between vitamin AD and neurodevelopment in children with brain injury.Vitamin AD level can reduce the risk of low development quotient of infants with brain injury,and can improve the neurodevelopment of children to a certain extent.