Study On The Correlation Between Gender Differences In Subjective And Objective Sleep And Neurological Injury Markers In Patients With Chronic Insomnia Disorder

Objective: Compare the subjective and objective sleep quality of men and women in chronic insomnia disorder(CID)patients,analyze the sleep structure of CID patients,and analyze the serum S100 calcium binding protein B(S-100B)and neuron specificity Whether there is a correlation with neuron-specific enolase(NSE).To explore the sex differences in sleep and serum nerve damage markers in CID patients.Methods:According to the "International Classification of Sleep Disorders" 3rd edition(International Classification of Sleep Disorders,ICSD-3)diagnostic criteria and enrollment principles,a total of 99 inpatients in Shenzhen Kangning Hospital from September 2019 to October 2020 were selected(39 males and 60 females).Collect basic data on subjects’ age,course of illness,education years,etc.Professionals use Pittsburgh Sleep Quality Index(PSQI)to assess subjective sleep quality,PSG(polysomnography)to assess objective sleep quality,and Eysenck personality test assessment Personality characteristics,self-rating depression scale(SDS)and self-rating anxiety scale(SAS)measure emotions.The fasting venous blood of all subjects was collected,and the levels of serum S-100 B protein and NSE were detected by Enzyme-linked Immunosorbent Assay(ELISA).SPSS26.0 were used to analyze the difference of subjective and objective sleep quality between CID male group and CID female group,and the relationship between sleep parameters and the levels of S-100 B protein and NSE.Results:1.The overall objective sleep quality of women in CID patients is better than that of men,and the proportion of women with emotions is higher than that of men(P value is 0.000).2.There was no statistical difference between the male group and the female group in CID patients in terms of age,disease course,education years,total subjective sleep quality score,body mass index,psychoticism,neuroticism and other personality dimensions(P>0.05).3.Compared with pure CID patients,CID patients with emotional problems performed worse in subjective sleep quality(P value 0.001).4.The serum NSE level of CID patients is negatively correlated with bedtime(r=-0.236,P=0.019),and positively correlated with the number of wakefulness and periodic limb movement index(r=0.212,P=0.035;r=0.232,P= 0.021);after controlling for age,disease course and other variables,it was shown that the serum NSE level was positively correlated with the number of wakefulness(r=0.409,P=0.000),and the NSE level was negatively correlated with the duration of the N2 phase(r=-0.235,P=0.024).5.Serum S-100 B levels in CID patients are negatively correlated with total sleep time,bed time,sleep efficiency,duration of phase R,and percentage of sleep time in phase R(r=0-0.310,P=0.002;r=-0.347,P=0.00;r=-0.286,P=0.04;r=-0.292,P=0.003;r=-0.252,P=0.012);S-100 B level is positively correlated with wake-up time after falling asleep(r=0.256,P =0.011);Partial correlation analysis was performed after controlling for age,disease course and other variables: serum S-100 B level was negatively correlated with total sleep time,bed time,and duration of R period.Conclusion:1.In patients with chronic insomnia,women are more likely to have emotional problems,and the objective sleep quality of male patients is not as good as that of women.2.The levels of serum S-100 B protein and NSE in patients with chronic insomnia are related to their sleep structure,suggesting that CID may have nerve damage.