| Objective: The purpose of this study is to explore the blood uric acid(UA)level,body mass index(BMI),systolic blood pressure(SBP)level,and diastolic blood pressure(DBP)level,total cholesterol(TC),triglyceride(TG),high density lipoprotein-cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),triglyceride glucose index(Ty G),triglyceride/high density lipoprotein-cholesterol(TG/HDL-C)and other metabolic risk indicators relevance.Methods: This study included a total of 702 adolescents and children diagnosed with short stature in the Department of Endocrinology,Affiliated Hospital of Jining Medical College from March 1,2013 to February 28,2019.The data were derived from the follow-up of growth and development diseases in Shandong Province Research cohort(Growth and Development Diseases in Shandong Province: a cohort follow-up study,GDDSD study,http://www.chictr.org.cn,Chi CTR1900026510).Collect general data of the research object such as gender,age,birth history,growth history,past history,and anthropometric indicators such as height,weight,blood pressure,and calculate their BMI,body mass index standard deviation integral(BMI SDS).Other laboratory test indicators include liver and kidney function,blood lipid profile,fasting plasma glucose(FPG),growth hormone peak(GH peak),insulin-like growth factor-1(IGF-1),and calculate the insulin-like growth factor-1 standard deviation score(IGF-1 SDS).All patients underwent growth hormone provocation test to determine the GH peak level.Divide the study population into two groups according to whether blood UA is greater than 5.5 mg/dl,compare the differences in clinical data indicators between the two groups,and analyze the correlation serum UA between BMI SDS,SBP,DBP,TG,TC,HDL-C,LDL-C,Ty G,TG/HDL-C,and perform a stratified analysis.Results:(1)Among adolescents and children with short stature,the group with UA≥5.5mg/dl has larger BMI SDS,higher GH peak,higher SBP,higher TG/HDL-C compared with UA<5.5mg/dl group,IGF-1 SDS and HDL-C levels are lower,and the difference is statistically significant;there is no significant difference in height SDS,DBP,TG,TC,LDL-C,FBG,Ty G and other indicators between the two groups.(2)Univariate analysis of serum UA and metabolic risk indicators in patients with short stature showed: serum UA was positively correlated with BMI SDS(β 0.12,95% CI 0.05,0.19;P<0.001),SBP(β 1.67 95%CI0.95,2.39;P<0.001),DBP(β 0.85 95%CI 0.32,1.39;P=0.002),TG(β0.03 95%CI 0.01,0.05;P=0.007),TG/HDL-C(β 0.08 95%CI 0.03,0.13;P=0.001),and negatively correlated with HDL-C(β-0.03 95%CI-0.05,-0.01;P=0.004),and was not correlated with TC,Ty G,LDL-C.(3)Smooth curve fitting shows that there is a non-linear relationship between serum UA and SBP in patients with short stature.Threshold effect analysis found that when UA<5.5mg/dl,serum UA was not correlated with SBP levels;when UA≥5.5 mg/dl,SBP increased with the increase of serum UA level(β 2.08,95% CI 0.17,4.00;P=0.033),the stratified analysis showed that there is a non-linear relationship between serum UA and SBP in ISS group,and there is no correlation between serum UA and SBP in GHD group.(4)Multivariate piecewise linear regression analysis showed that after adjusting for confounding factors,serum UA levels were still are positively correlated with BMI SDS(β 0.07,95%CI 0.01,0.14;P=0.034),TG(β 0.02 95%CI 0.01,0.04;P=0.043),TG/HDL-C(β 0.06 95%CI 0.01,0.11;P=0.024),and negatively correlated with HDL-C(β-0.02 95%CI-0.04,-0.01;P=0.033),the stratified analysis was similar with the whole in both GHD and ISS group.Conclusions: In adolescents and children with short stature,serum UA levels have a linear positive correlation with BMI SDS,TG,TG/HDL-C,a linear negative correlation with HDL-C,and a nonlinear relationship with SBP.When the serum UA level is less than the 5.5mg/dl,the serum UA was not correlated with SBP,and when the serum UA is greater than 5.5 mg/dl,the serum UA and SBP are linearly related. |
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