Correlation Analysis Between Cognitive Dysfunction And Serum BDNF Factor In Patients With OSAHS

Objective:To determine the relationship between the blood serum brain-derived neurotrophic factor(BDNF)level and cognitive function deterioration in patients with obstructive sleep apnea/ hypopnea syndrome(OSAHS).Methods:A total of 61 patients with primary diagnosis of OSAHS who were admitted to the Hospital of Jilin University from December 2019 to December 2020 due to chief complaints of snoring and daytime drowsiness were selected.According to the PSG,18 patients were divided into mild and moderate group,43 patients were divided into severe group,and 15 healthy subjects were selected as control group.Sixty-one patients in the OSAHS group,ranging in age from 19 to 73 years old,were 52 males and 9females.A control group of 15 patients,ranging in age from 24 to 60 years old,included11 males and 4 females.Part Ⅰ:76 subjects to adopt simple mental state examination scale(Mini-getting the state examination,MMSE),Montreal Cognitive Assessment scale(Montreal Cognitive Assessment,MoCA)Cognitive function Assessment,a total score 26 divided into Cognitive function is normal,or < 26 is divided into Cognitive dysfunction,and statistical analysis of data using SPSS26.0 p < 0.05,there is statistical significance,summarizes the incidence of OSAHS Cognitive dysfunction and clinical characteristics.Part Ⅱ: 32 patients from 61 OSAHS patients and 11 healthy subjects from the control group were selected to measure the level of serum BDNF in the peripheral vein by ELISA.Correlation analysis was conducted between serum BDNF value and PSG test data and cognitive scale score respectively.The statistical method was the same as that in Part I.Results:Part Ⅰ: 1.Analysis of general data between the OSAHS group and the control group: the years of education between the two groups were approximately the same(13±4/14±3,p=0.12),and the ages were approximately the same(40±12/37±13,p=0.47).There was no statistical difference.2.The total scores of MoCA and MMSE in the OSAHS group were significantly decreased,which was statistically significant compared with the control group,specifically manifested in visuospatial executive ability,computational ability,language ability,and delayed recall.3.There was no significant correlation between cognitive function score and PSG in 61 patients with OSAHS group,and 43 patients with severe OSAHS were selected for correlation analysis: MoCA,MMSE total score was negatively correlated with REM(r=-0.342,r=-0.327,p< 0.05),and language ability and abstract ability were negatively correlated with AHI(r=-0.389,r=-0.400,p<0.05).4.Correlation between cognitive dysfunction and general data: The cognitive function and general data of 61 patients with OSAHS were statistically analyzed.There was a moderate positive correlation between total cognitive function score and years of education(r=0.410,r=0.204,P < 0.05),a low positive correlation between visual spatial executive ability and years of education(r=0.336,P< 0.05),and a low negative correlation between naming ability and age(r=-0.276,P <0.05).Language and abstract ability were negatively correlated with BMI(r=-0.412,r=-0.260,P < 0.05),and the difference was statistically significant.Part Ⅱ:1.Comparison of serum BDNF levels: 43 serum samples from different weeks,including 9 cases in the mild and moderate group,23 cases in the severe group,and 11 cases in the control group.The data were consistent with normal distribution.The BDNF values of the three groups were compared by analysis of variance.According to MMSE score,32 samples from OSAHS group were divided into those with or without cognitive impairment,8 cases in the cognitive impairment group,and24 cases with normal cognitive function.Serum BDNF level in the cognitive impairment group was significantly lower than that in the cognitive normal group(2670±2779/9223±9223,p<0.05).2.Correlation analysis of cognitive impairment and serum BDNF level: MMSE score was positively correlated with BDNF level(r=0.362,p=0.017),language ability was positively correlated with BDNF level(r=0.362,p=0.03),visuospatial executive ability was positively correlated with BDNF level(r=0.444,p=0.017);3.Correlation analysis of serum BDNF level with general data and PSG indicators in 32 patients with OSAHS: BDNF level was negatively correlated with age(r=-0.303,p=0.048)and with AHI(r=-0.362,p= 0.0422).Conclusions:1.Patients with OSAHS have mild cognitive impairment,which is manifested in three aspects,namely,computing ability,language ability and delayed recall,among which severe patients also have decreased visuospatial executive ability;2.Disorder of sleep structure in patients with severe OSAHS is related to cognitive dysfunction,and REM period may play an important role in the influence on cognitive function;3.Based on MMSE score,cognitive dysfunction in OSAHS patients was associated with peripheral serum BDNF factor,and the more severe the cognitive impairment,the lower the BDNF factor.