Association Between Fatty Acid Intake And Cancer

Objective:Cancers will be the main cause of death for humans in each countries in the 21st century,and an important obstacle to increase life expectancy.Although the incidence and mortality of cancer in various countries are different,they all show an upward trend year by year.In recent years,many studies have focused on the influence of dietary fatty acid intake on cancers,they showed that fatty acids can influence or induce cancer immunosuppression through different mechanisms,and most of them are cancer influencing factors obtained by comprehensively considering multiple risk factors.Few studies have explored the relationship between fatty acid intake and cancers by eliminating the influence of confounding factors such as age and gender.In response to conflicting reports that different types of fatty acids can inhibit or promote the occurrence and expression of cancer,this study explores the relationship between fatty acid intake and various cancers,so as to provide a basis for the primary prevention of cancers from the perspective of fatty acid intake.Methods:The data of this study comes from the NHANES database of the National Health and Nutrition Survey of the United States,and select total 9 cycles of study from 1999 to 2016.The cancers include skin cancer,colorectal cancer,lung cancer,prostate cancer,breast cancer,cervical cancer,ovarian cancer,7 species cancers.The research objects of experimental group are who only suffers from a certain type of cancer,and the research objects of control group are who does not suffer from any kind of cancers,and then adopt the 1:4 propensity score matching method to form the control group after matching gender,age,education level,marital status,drinking,smoking,BMI,hypertension,and diabetes.According to the gender of men and women to describe the basic characteristics of a variety of cancer experimental group and control group.The quantitative datas are expressed as mean±standard error,and two-sample t-test is used to compare differences between groups;According to the stratified analysis of gender.The qualitative datas are expressed by frequency and percentage,and the difference is tested by Rao Scott-χ~2 test;And use Pearson linear correlation to analyze the correlation of different types of fatty acid intakes,and then use binary logistics to perform regression analysis.Results:1.There are 959,252,92,601,571,269 and 94 patients with skin cancer,colorectal cancer,lung cancer,prostate cancer,breast cancer,cervical cancer,and ovarian cancer,respectively;Among them,all prostate cancer patients are men,Breast cancer,cervical cancer,and ovarian cancer patients are all women,the remaining cancers exist in both men and women;and the female cancers are stratified according to whether they are menopausal or not to describe the basic characteristics of the cancer experimental group and the control group;2.In men:Saturated fatty acid intakes,monounsaturated fatty acid intakes and polyunsaturated fatty acid intakes are both associated with the risk of skin cancer.There is no association between fatty acid intakes and skin cancer in women;Saturated fatty acid intakes and polyunsaturated fatty acid intakes is associated with the risk of prostate cancer;3.In premenopausal women with breast cancer,monounsaturated fatty acid intake is associated with female breast cancer[0.37(0.11,0.78)],and no such correlation has been found in postmenopausal women;4.None of the other cancers specifically listed in this study found a correlation between fatty acid intake and cancers.Conclusion:1.In male skin cancer,increasing saturated fatty acid intake,monounsaturated fatty acid intake,and polyunsaturated fatty acid intake may be positively associated with the increased risk of male skin cancer.2.In men with prostate cancer,increasing the intake of saturated fatty acids and polyunsaturated fatty acids may be positively associated with the increased risk of prostate cancer.3.In premenopausal women with breast cancer,increasing the intake of monounsaturated fatty acids may be positively associated with the decrease in breast cancer risk.