Study On The Relationship Between Sleep Oxygen Desaturation,Serum 25(OH)D And Behavioral Problems In Children

Objective:To analyze the relationship between the severity of sleep oxygen desaturation and serum 25（OH）D content in children with SDB through monitoring the blood oxygen saturation,serum 25（OH）D content and results of Conners’Brief Symptom Questionnaire.To explore the correlation between the sleep oxygen desaturation and the risk of behavioral problems in children with SDB,and to provide evidence for the prevention and comprehensive treatment of SDB and attention deficit and hyperactivity disorder（ADHD）.Methods:A total of 78 children who visited the Department of Otolaryngology,Second Hospital of Jilin University from October 2019 to December 2020 with the chief complaint of"snoring and feeling suffocated at night"were included.The finger pulse oxygen was monitored during sleep at night,and the severity of SDB was classified according to the Lowest oxygen saturation（LSaO₂）.The guardians of the children were instructed to fill in the Conners’Brief Symptom Questionnaire.Fasting peripheral venous blood samples were collected from children,and the serum 25（OH）D level was determined by ELISA.The data and clinical data were statistically analyzed.The significance level was regarded as p<0.05.Results:1.The mean serum 25（OH）D content of children in moderate-severe group and mild group were（14.73±8.53）ng/ml and（21.75±8.78）ng/ml,respectively,with statistical significance（p=0.001）.2.In moderate-severe group,the serum 25（OH）D content of children was positively correlated with LSaO₂（r=0.442,p=0.011）,the adenoid hypertrophy score was negatively correlated with age（r=-0.465,p=0.007）,and BMI was positively correlated with age（r=0.386,P=0.007）.3.In mild group,the adenoid hypertrophy score was negatively correlated with age（r=-0.324,P=0.028）.4.A total of 74 Conners’Brief Symptom Questionnaires were obtained,of which 9 children scored≥15,accounting for 12.16%.5.In moderate-severe group,the scores of Conners’Brief Symptom Questionnaire were negatively correlated with LSaO₂（r=-0.425,p=0.024）.Conclusions:The level of serum 25（OH）D content in children with SDB who had a severe decrease in sleep oxygen desaturation,and the decrease of serum 25（OH）D content was correlated with the severity of SDB in children.The persistence and aggravation of sleep-disordered breathing may increase the risk of children’s behavior problems.