Comparison Of Resting Brain Function Changes In Depression With/without Insomnia Symptoms

Research purposes:Use of resting state functional magnetic resonance imaging(f MRI),using local consistency(regional homogeneity,Re Ho)and functional connections(functional connectivity,FC)analysis method,respectively,to explore the synchronicity of local neuronal activity and the synchronicity between the medial prefrontal cortex(MPFC)and the whole brain activity in depressive patients with and without insomnia symptoms.In this way to explore whether there is abnormal brain function and analyze the commonality and specificity of the abnormal brain function between the two,in the end,to understand the two-way relationship between depression and insomnia.Materials and methods:Meets the Chinese classification and diagnostic criteria of mental disorders related to the diagnostic criteria for mild depressive episodes,24 Hamilton Depression Scale(Hamilton Depression Scale,HAMD)score ≥ 7 points,considered as a depressive state.And according to the Pittsburgh sleep quality index(PSQI)6 points,patients with depression are divided into two groups: depression with insomnia symptoms and depression without insomnia symptoms,and patients in the depression with insomnia symptoms group need to comply with the United States Psychiatric Association(APA)"Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition,DSM-5)diagnostic criteria for chronic insomnia.Finally,26 depressive patients with insomnia symptoms,5 depressive patients without insomnia symptoms,and 16 healthy volunteers matching the patient group’s age,gender,education level,etc.were collected as the normal control group.The three groups of subjects all completed rs-f MRI scans,and used DPARSFA(Data processing assistant for resting-state f MRI http://www.restfmri.net/forum)software based on Matlab(R2011a)platform to perform image preprocessing.Matlab(R2011a)platform’s dpadi software(http://rfmri.org/dpabi)and SPM12 software(Statistical parametric mapping http://www.fil.ion.ucl.ac.uk/spm/)are used for the three groups of Re Ho data and FC data do a single-sample T test,and then do a two-sample T test between groups,and remove the age and gender of the two as covariates,The double-sample t-test results of Reho value and FC value in the pair-wise control group between the three groups were respectively conducted,The removal was performed using the method of displacement test,and P < 0.01 was considered to be statistically significant.And do comparison between three groups of two,comparison between groups Re Ho,FC,increase or decrease in the area.Result:1.Compared with the normal control group,in the depression with insomnia symptoms group,the Re Ho value of the left precuneus and the left middle cingulate gyrus increased,and the FC between the right medial superior frontal lobe and the medial prefrontal lobe decreased.2.Compared with the normal control group,in the depression without insomnia group,the Re Ho value of the left middle cingulate gyrus increased,the Re Ho value of the right cuneus lobe decreased,the FC between the left anterior cingulate gyrus and the medial prefrontal lobe decreased,and the FC between right precuneus and the medial prefrontal lobe increased.3.Compared with the depression with insomnia symptoms group,in the depression with insomnia symptoms group,the Re Ho value of the left inferior temporal gyrus decreased.The FC between the right precuneus and medial prefrontal lobe decreased,while the FC between the left anterior cingulate gyrus and medial prefrontal lobe increased.4.The different brain regions obtained in the depression with and without insomnia symptoms groups were compared with the normal control group respectively.The intersection brain area is the left middle cingulate gyrus.5.The depression with insomnia symptoms group were compared with the depression without insomnia symptoms group and the normal control group respectively.The different brain regions obtained were overlapped,and the overlap area was the precuneus.6.Depressive patients with / without insomnia symptoms are accompanied by a wide range of brain network dysfunctions,including default networks(medial prefrontal lobe,precuneus),salience network(anterior cingulate gyrus),etc.,and also involve cognitive control And emotional processing(frontal lobe,cuneus lobe,anterior cingulate gyrus)related neural circuit abnormalities.Conclusion:1.The left middle cingulate gyrus,the right cuneus gyrus,the left anterior cingulate gyrus,and the right precuneus has important significance in the pathogenesis of depression.2.The precuneus can be used as a specific imaging marker for the subtypes of depression with insomnia.3.Depressive patients with / without symptoms of insomnia may be associated with dysfunctions of extensive brain networks and neural circuits,which may be associated with dysregulation of related neurotransmitters.Therefore,this study provides new directions and evidence to explore the pathogenesis of depression with or without insomnia symptoms.