| Objective:To study serum 25-hydroxyvitamin D status of children in Changchun City and analyze its characteristics and influence factors,to provide reference basis for reasonable vitamin supplement clinically.Methods:Children aged 0-17 were randomly selected from the pediatric outpatient department of China-Japan Union Hospital of Jilin University,according to inclusion and exclusion criteria,a total of 1204 children were selected as subjects.According to age,they were divided into five groups: infant period(>28days,<1year),toddle period(1-3years),preschool age(4-6years),school age(7-11years)and adolescence(12-17years).The serum 25-hydroxyvitamin D level was determined by fluorescence immunoassay.At the same time,they were divided into spring/summer group,autumn/winter group according to the time of test.The results were statistically analyzed using SPSS 26.0 software,the average serum levels of 25-hydroxyvitamin D in children of different ages and different seasons were compared.2011 parents of 0-17-year-old children were randomly selected from all social stratum in Changchun City to fill in the questionnaire to obtain the information of their children’s age,vitamin D supplement,average outdoor exercise time and so on.Results:1.The average level of serum 25 hydroxyvitamin D in 1204 children was 27.00± 10.92ng/m L,in which the adequacy rate,deficiency rate,deficiency rate and severe deficiency rate of vitamin D were 31.06%,38.04%,30.56% and 0.33%,respectively.No excessive or insufficient vitamin D was found.2.Comparison between different age groups,the serum 25-(OH)D average level was the highest in the toddle period group,which was 32.30±11.69 ng/m L;followed by infant period group,which was 29.69±11.76ng/m L;then the preschool age(23.81±7.52ng/m L)and school age(23.43±8.26ng/m L),the serum 25-(OH)D average level was the lowest in the adolescence group,which was 20.45±7.10ng/m L.There were statistical differences in the level of 25-(OH)D status among all different age groups(P<0.05).Except there was no statistical difference in the level of serum25-(OH)D status between preschool age group and school age group,there was statistical difference in the average level of serum 25-(OH)D status between any two different age groups(P<0.05).The vitamin D sufficiency rates of infant period,toddle period,preschool age,school age and adolescence groups were 41.6%,49.6%,18.8%,14.9% and 12.0%,respectively.There were statistical differences in vitamin D adequacy among different age groups(P<0.05).3.Comparison between different seasons,the average level of serum 25-(OH)D status in children in spring/summer was 28.68±12.62ng/m L,and that in autumn/winter was 26.09±9.75ng/m L,with statistical significance(P<0.05).The vitamin D sufficiency rate in spring/summer was 38.2%,and that in autumn/winter was 27.2%,with statistical significance(P<0.05).4.Among the 2011 children in Changchun city,the rates of regular and moderate vitamin D supplementation and irregular/insufficient vitamin D supplementation showed a decreasing trend with the increase of age,while the rates of no vitamin D supplementation showed an increasing trend.The proportion of ≥1 hour outdoors per day in infant period,toddle period,preschool age,school age and adolescence children were 33.79%,57.04%,39.67%,32.90% and 17.47%,respectively.Conclusions:1.The vitamin D nutrition level of children in Changchun city is low as a whole,with the lowest in the adolescent children.2.All ages children in Changchun City need to increase outdoor activities appropriately and supplement vitamin D reasonably,especially for adolescent,school age and preschool children;It is necessary to increase the dose of vitamin D in autumn and winter.3.Vitamin D related health propaganda and education needs to be further popularized. |
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