Analysis Of Bronchiectasis-Chronic Obstructive Pulmonary Disease Overlap Syndrome’s Clinical Features And Prognosis

Objective:We retrospectively studied the general information,symptoms,laboratory test indicators,imaging indicators,and lung function of patients,who had bronchiectasis-chronic obstructive pulmonary disease overlap syndrome（BCOS）.The purpose is to explore the clinical characteristics and poor prognostic indicators of the disease,and to pay more attention to the disease in clinical work,timely diagnosis and timely treatment,so as to improve the quality of life of patients.Methods:We collected a total of 165 patients with definitely diagnosed chronic obstructive pulmonary disease（COPD）and BCOS who were hospitalized in the Department of Respiratory Medicine,China-Japan Union Hospital of Jilin University from January2019 to December 2019 for analysis.Their data of gender,age,smoking history,allergy history,body mass index（BMI）,length of hospitalization,clinical symptoms,white blood cell count,neutrophil count,lymphocyte count,neutrophil/lymphocyte ratio,platelet count,hemoglobin,red blood cell volume distribution width,procalcitonin,pulmonary function,PO₂,PCO₂,whether it is combined with pulmonary hypertension,whether it is combined with respiratory failure,history of tuberculosis,sputum culture,chest CT and other data.Statistical analysis of collected data was performed using SPSS25.0 statistical analysis software.Result:1.In the previous history of tuberculosis,the BCOS group was significantly higher than the COPD group,P<0.05,the difference was statistically significant.The length of hospital stay in the BCOS group was significantly higher than that in the COPD group（P=0.09）.2.COPD patients had more sputum and shortness of breath symptoms than BCOS patients（P<0.001,P=0.004）,the difference was statistically significant. However,patients with BCOS had more symptoms of hemoptysis than patients with COPD,（P=0.001,P<0.05）,and the difference between the two groups was statistically significant.3.The PO₂of the BCOS group was significantly lower than that of the COPD group, P=0.004,so the difference was statistically significant;however,the PCO₂ of the BCOS group was higher than that of the COPD group,P=0.002,and the difference was statistically significant.4.The white blood cell count,neutrophil count,neutrophils/lymphocytes,and procalcitonin of patients in the BCOS group were higher than those in the COPD group,and the P values were less than 0.05,respectively,and the differences were statistically significant（P=0.001;P=0.001;P=0.001;P=0.022）.5.FEV1%was significantly lower in the BCOS group than in the COPD group,P= 0.03,that is,there was a significant difference between the two groups.The number of severe and very severe patients in the BCOS group was significantly more than that in the COPD group,P=0.014,so the difference was statistically significant.6.The P values of hospital stay,previous history of tuberculosis,Pseudomonas aeruginosa infection and hemoptysis were less than 0.05,respectively,which were independent risk factors of chronic obstructive pulmonary disease with bronchiectasis.7.The BCOS group experienced more pulmonary hypertension and respiratory failure than the COPD group,(P=0.04,P<0.01 and the difference was statistically significant.Conclusion:1.Compared with patients in the simple COPD group,BCOS patients have longer hospital stays,worse lung function,and heavier inflammation indicators.It suggests that the two diseases are superimposed,which can lead to aggravation of obstructive pulmonary dysfunction.NLR has clinical significance for patients with bronchiectasis.2.Longer hospital stay,previous history of tuberculosis,combined with Pseudomonas aeruginosa infection,hemoptysis,are independent risk factors for BCOS patients.3.The typical imaging manifestations of bronchiectasis mainly occur on both sides,and the incidence of columnar expansion is relatively high.4.The incidence of BCOS patients with pulmonary hypertension and respiratory failure is higher than that of the COPD group.