| Objective: To investigate the effect of anxiety symptoms on cognitive function of patients elder population,and to clarify the effects of anxiety symptoms on neural activity and function in related brain regions by using resting-state functional magnetic resonance imaging(rs-f MRI).Methods: The elderly who volunteered to participate in cognitive function screening at Heping Road Community Health Service Center in Nanchong City were recruited.Finally,15 patients were enrolled in the MCI group with anxiety symptoms(MCI +),29 patients were enrolled in the MCI group without anxiety symptoms(MCI-)and 21 patients were enrolled in the normal control group(NC).All subjects were required to complete a complete set of systematic neuropsychological scales and other relevant exclusion scales,and underwent rs-f MRI scans.The differences in neuropsychological scale results,amplitude of low-frequency fluctuation and functional connectivity of anxiety-related brain regions among the three groups and between the MCI+and the MCIgroups were calculated and analyzed.Furthermore,the correlation coefficient between ALFF value and neuropsychological scale score in MCI+ group was analyzed and calculated.Results:1.Significant differences were found among three groups in the scores of the Mini-mental State Examination(MMSE),Montreal Cognitive Assessment Basic(Mo CA-B),delayed recall scores(N5)and recognition scores(N7)of Auditory Verb Learn Test-Huashan Version(AVLT-H),Boston Naming Testing(BNT)and Shape Trails Test(STT)A & B.There was no statistical difference in the scores of Animal Verbal Fluency Test(AFT)among the three groups.The MMSE and AVLT-N7 scores in MCI + group were significantly higher than those in MCI-group.Compared with the NC group,there was no significant difference in AFT between MCI+ and NC group,and all other scores in MCI + group and MCI-group were statistically significant.2.The ALFF results showed that the ALFF of the left inferior occipital gyrus and the right superior parietal lobule were significantly different among the three groups.Compared with the MCI-group,the brain areas with reduced ALFF in the MCI+ group included the left precuneus,left posterior cingulate cortex,left superior temporal gyrus,and right medial superior frontal gyrus.The brain areas with increased ALFF included the right inferior parietal lobule and the right superior parietal lobule.3.Correlation analysis showed that ALFF values of the right inferior parietal lobule in the MCI + group were significantly negatively correlated with STT-B scores.4.FC results showed that compared with the MCI-group,the MCI + group had significantly decreased FC value in four brain regions: dorsomedial prefrontal cortex and left anterior insula,left cerebellum and left anterior insula,anterior cingulate gyrus and posterior central gyrus,and left superior temporal gyrus and right superior temporal gyrus.Conclusion:1.Anxiety symptoms can aggravate the impairment of cognitive function in MCI patients,especially in terms of overall cognitive function and memory function;2.The abnormal neural activity and functional connectivity of multiple brain regions in MCI patients with anxiety symptoms may be related to their neuropathological mechanism. |
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