Magnetic Resonance Spectroscopy Study Of The Frontal Lobe Of Patients With Generalized Anxiety Disorder

Objective: 1H-Magnetic Resonance Spectrum(1H-MRS)imaging method was used to obtain the changes of metabolites in the frontal lobe of patients with generalized anxiety disorder(GAD),and to explore and study the pathogenesis of GAD.Methods: A total of 20 cases in the case group of this study came from patients who were clearly diagnosed as GAD by the First Affiliated Hospital of Dali University from June 2019to December 2020.The control group selected volunteers to participate in the study,and they also met the Hamilton anxiety and depression scores.Table standard 20 cases of healthy people.Head MRI spectroscopy detected bilateral prefrontal choline complex(choline,Cho),creatine(Cr),N-acetylaspartic acid(NAA),and The peak heights of myo-inositol(m I)were calculated as the ratios of NAA,Cho,m I and Cr respectively,and the differences in the concentration of metabolites between the two groups of subjects and within each group were compared.All data were statistically analyzed by spss22.0 software,according to a = 0.05 test level,P < 0.05(bilateral test)as the difference was statistically significant.Results:1.The ratio of NAA/Cr in the GAD group in the right prefrontal lobe was higher than that in the control group at the same site,and the difference was statistically significant(P<0.05).The ratio of NAA/Cr in the GAD group in the right prefrontal lobe was higher than that in the left.The difference was statistically significant(P<0.05),and the ratio of NAA/Cr in the left prefrontal lobe in the GAD group was not significantly different from the control group at the same site(P>0.05).2.There was no statistically significant difference between the ratio of Cho/Cr in the bilateral prefrontal lobe between the GAD group and the control group at the same site(P>0.05).3.The ratio of m I/Cr in the GAD group in the bilateral prefrontal lobes was higher than that in the same part of the control group,and the difference was statistically significant(P>0.05).Conclusion: 1.In patients with generalized anxiety,the right prefrontal neuron metabolism disorder and hyperfunction(NAA/Cr ratio),and the left and right abnormalities have asymmetry.2.There was no significant changes in neuronal membrane phospholipid metabolism(Cho/Cr ratio)in generalized patients.3.Patients with generalized anxiety have increased levels of inositol metabolism in the frontal lobe.