Relationship Between Classical Transient Receptor Potential Channel 1 Gene Polymorphism And Microalbuminuria In Patients With Essential Hypertension

Objective:To investigate the relationship between classical transient receptor potential channel 1(TRPC1)gene polymorphism and microalbuminuria in patients with essential hypertension.Methods:A total of 470 patients(322 males and 148 females)with essential hypertension who were hospitalized and diagnosed in the Department of Hypertension from the First Affiliated Hospital of Xinjiang Medical University during April 2015 and November 2017 were recruited.The patients were divided into microalbuminuria group(n=72)and normal-microalbumin group(n=398)according to microalbuminuria.Single nucleotide polymorphism(SNP)site rs1382688,rs3821647,rs7638459,rs953239,and rs7621642 of the TRPC1 gene were genotyped using Sequenom detection technology.Results:Compared with normal-microalbumin group,body mass index(BMI)[(28.2±4.1)vs(26.3±3.2)kg/m~2],24-hour mean systolic blood pressure[(144.5±17.2)vs(133.5±12.9)mm Hg],and 24-hour mean diastolic blood pressure[(93.0±13.7)vs(84.6±11.1)mm Hg]were statistically increased,while age decreased[(43.5±10.2)vs(47.7±9.9)years]in microalbuminuria group(P<0.05).There were no significant differences in the gene distribution frequencies of SNP site rs1382688,rs3821647,rs953239,and rs7621642 in the TRPC1 gene between the two groups(P>0.05),while rs7638459 in the genotype,allele and invisible model distribution frequencies were statistically different.Logistic regression analysis showed that BMI and CC genotype at rs7638459 were risk factors for increased microalbuminuria in patients with essential hypertension.Conclusion TRPC1 gene polymorphisms are associated with increased microalbuminuria in patients with essential hypertension,the CC genotype of rs7638459 may increase the risk of microalbuminuria in patients with essential hypertension.