Analysis Of Recurrence Related Factors In Patients With Negative Cutting Edge After Conization For High-grade Cervical Intraepithelial Lesions

Objective:The purpose of this study was to investigate the related factors of recurrence of cervical lesions in patients with high cervical squamous intraepithelial lesions after conical resection and patients with negative surgical margin。Methods:from January 2015 to March 2018,the patients who visited our department for high-grade cervical lesions and underwent LEEP or cold knife conization were selected.Among the patients with negative surgical margin after conization,the parties with recurring lesions were selected as a case group(33 cases in total),and the parties without recurring lesions were selected as a control group(94 cases in total)..Age,BMI,menstrual cycle,days of behavior,times of pregnancy and childbirth,menopause,type of HPV infection before operation,HPV load,grade of lesion before operation,liquid based cytology,different operation methods,whether the lesion involved glands,HPV infection after operation,whether there was lesion in cervical canal and other factors were analyzed Related factors of recurrence in negative patients。Results:In the recurrence group,the proportion of postmenopausal patients with high-grade cervical lesions and recurrence after conization was higher than that in the control group,and the difference was statistically significant(0r=3.109,P<0.05).In the recurrence group,patients with high-risk HPV infection before operation accounted for more than those in the control group.The data comparison results between the two groups were significantly different,which had important statistical significance(0r=3.185,P<0.05).In the recurrence group,the patients with abnormal liquid based cytology(including as-cus,ASC-H,LSIL and HSIL)were more than those in the control group,and the difference between the two groups was statistically significant(0r=5.055,P<0.05)。Conclusion:Menopause,postoperative cytological abnormalities,preoperative infection of high-risk HPV are the independent related factors of postoperative recurrence in patients with negative cervical HSIL conization margin.In clinical practice,we should strengthen the postoperative follow-up and management of patients with these factors。...