| ObjectiveIn this research,magnesium alloy materials were introduced into the field of dental implantology based on the biodegradable characteristics of magnesium alloy materials.The feasibility of magnesium alloy membrane as a barrier membrane in guiding bone regeneration technology was explored by analyzing the physical and chemical properties,physical properties and biological safety of the materials,so as to provide data support for further clinical application research.Methods1.Sr-HA coating was prepared on the surface of magnesium alloy by micro-arc oxidation/double pulse electrodeposition process.2.SEM,EDS,XRD,FT-IR,binding strength,wettability and other analysis methods were used to characterize the microstructure and physical properties of the coating,and the optimal strontium content was selected preliminarily.3.With magnesium alloy bare matrix as the control,the degradation behavior of biological barrier membrane of hydroxyapatite magnesium alloy with different strontium content in simulated body fluid immersion process was studied by electrochemical method.4.The best strontium-doped magnesium alloy biological barrier membrane was screened by CCK-8 method,the cytotoxic reaction was detected,the cytotoxic grade was analyzed,and the feasibility of application of strontium-doped magnesium alloy biological barrier membrane in oral implantation and repair was comprehensively evaluated.Results1.Sr-HA coating was successfully prepared on magnesium alloy by micro-arc oxidation/double pulse electrodeposition process.2.The results of SEM,EDS,XRD and other tests show that when the strontium doping amount is 15at%,the coating presents a uniform and compact needle like structure,the binding strength is 30.6 MPa,the wettability is 19.68°,and the coating thickness is 15.84μm.3.The electrochemical corrosion test showed that the corrosion current density of SR-HA coated magnesium alloy decreased by 2 orders of magnitude,and the self-corrosion potential increased by about 20 mV compared with the magnesium alloy bare matrix.The results of simulated body fluid immersion showed that the SR-HA coating had a protective effect on the bare matrix of magnesium alloy and could delay the degradation of magnesium alloy.4.The results of in vitro cytological experiments showed that SR-HA coated magnesium alloy biological barrier membrane did not cause cytotoxic reaction and could meet the biosecurity requirements of bone implant materials.ConclusionSr-HA coated magnesium alloy biological barrjier membrane has good mechanical properties,corrosion resistance and biological safety,and has a broad application prospect in guiding bone regeneration.However,further exploration and research on the biocompatibility and osteogenic effect of the material in vivo are still needed to apply it into clinical practice. |
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