Prognostic Factors Of 85 Patients With Primary Thymus Epithelial Tumor After Surgical Treatment

Objective: To investigate the clinico Pathological features and Prognostic factors of Primary TETS Patients after surgical treatment.Methods: The 85 Patients’ clinical data with Primary TETS who received surgical treatment in the De Partment of Thoracic Surgery of the Affiliated Cancer Hos Pital of Xinjiang Medical University from January 1,2010 to Se Ptember 30,2018 were retros Pectively analyzed.In this study,all Patients underwent com Plete resection of TETS and the Posto Perative staging was clear.The follow-u P information of all Patients was com Plete.Ka Plan-Meier method and Cox model(univariate and multivariate)were used for Prognosis Prediction analysis.Results: A total of 85 Patients with thymus e Pithelial tumor were analyzed for clinico Pathological data and survival.After analysis,it was found that Masaoka-Koga staging and TNM staging had a low correlation with WHO tissue ty Pes,and the difference was statistically significant(r=0.435,0.413 P<0.001).TNM staging was significantly correlated with Masaoka-Koga staging,and the difference was statistically significant(r=0.898 P<0.001).Among the TNM and Masaoka-Koga staging systems,the Masaoka-Koga staging system is more accurate in Predicting the Prognosis of Patients with Primary thymic e Pithelial neo Plasms undergoing radical surgical resection.During long-term follow-u P(median time: 68 months,range 1 to 131 months),the 3-year and 5-year survival rates of Patients with com Plete surgical resection of thymic e Pithelial neo Plasms were 94.1% and 84.3%,res Pectively.Univariate analysis showed that tumor size,surgical method,WHO histological classification,Masaoka-Koga stage,T stage,lym Ph node metastasis and TNM stage had significant effects on the long-term survival rate of Patients with thymic e Pithelial tumor(P<0.05).The multivariate Cox analysis showed that tumor size(HR =2.283/2.332,95%CI:(1.161-4.490)/(1.171-4.645),P=0.017/0.016),Masaoka-Koga stage(HR=3.298,95%CI: 1.584-6.867,P=0.001)and TNM stage(HR=2.692,95%CI:1.467-4.939,P=0.001)were all inde Pendent factors affecting the survival rate after thymic e Pithelial tumor o Peration.Conclusion: 1.Tumor size: Masaoka-Koga stage and TNM stage are inde Pendent factors affecting the Prognosis of Patients with thymic e Pithelial neo Plasm.2.Masaoka-Koga stage is more accurate in Predicting the Prognosis of Patients with Primary thymic e Pithelial neo Plasm undergoing radical surgical resection.