| Objective To evaluate the clinical efficacy,safety,onset time and recurrence rate of Xingpi Huashi Decoction in treating diarrhea predominant irritable bowel syndrome.Methods Ninety patients who met the inclusion and exclusion criteria were divided into treatment group and control group.The treatment group was treated with Xingpi Huashi Decoction,while the control group was treated with pivoxil bromide tablets for 4 weeks.The IBS symptom scale,IBS defecatetion state questionnaire,Traditional Chinese Medicine pattern curative effect scoring system,IBS quality of life questionnaire,Hamilton Anxiety Scale and Hamilton Depression Scale of the patients were observed and recorded before and after treatment.The overall clinical efficacy,stool characteristics and defecation,TCM syndrome efficacy,quality of life and mental status of the two groups were compared and evaluated.Results 1.A total of 134 patients with IBS-D of spleen deficiency and dampness obstruction type were included.133 patients were in accordance with FAS,including 66 patients in the treatment group and 67 patients in the control group.There were 126 PPS patients,62 in the treatment group and 64 in the control group.2.After 2 weeks of treatment,the total effective rates of the treatment group and the control group were improved(FAS:56.06%,46.27%;PPS:54.84%,51.56%),and the difference was not statistically significant(P>0.05).After 4 weeks of treatment,the total effective rates of the treatment group and the control group(FAS:87.88%,55.22%;PPS:90.32%,65.63%),and the difference was statistically significant(P<0.01).After 2 weeks of treatment,the difference was statistically significant in the treatment group(P<0.01),and there was no significant difference in the control group(P>0.05).After 2 weeks of treatment,the ibs-bss scores and total scores of the two groups were improved(P<0.01),and the life disturbance of the single treatment group was better than that of the control group(P<0.05),After 4 weeks of treatment,the scores and total scores of the treatment group were better than those of the control group(P<0.05,P<0.01);after 4 weeks of treatment,the scores and total scores of the treatment group were better than those of the control group(P<0.01),and the defecation satisfaction,life disturbance and total scores of the control group were better than those of the control group(P<0.01).3.The total effective rate(FAS:80.30%,59.70%,PPS:85.48%,62.50%)was significantly different(FAS:P<0.05,PPS:P<0.01).After 4 weeks of treatment,the total effective rate(FAS:93.94%,70.15%,PPS:93.94%,70.15%)was significantly different between the two groups(P<0.05).The curative effect of the treatment group after 4 weeks was better than that after 2 weeks(P<0.05),and there was no significant difference in the control group(P>0.05).After 2 weeks of treatment,the defecation situation of the two groups was improved(P<0.01);after 4 weeks of treatment,the defecation situation of the two groups was improved(P<0.01);the defecation situation of the treatment group was better than that of the treatment group(P<0.01),and the defecation urgency days and defecation character grade of the control group were significantly improved(P<0.05,P<0.01).4.Comparison of quality of life:after 2 weeks of treatment,the scores and total scores of the two groups were significantly improved compared with those before treatment(P<0.01),the emotional status,mental state and total scores of the treatment group were better than those of the control group(P<0.01,P<0.05);after 4 weeks of treatment,the two groups were better than those before treatment(P<0.01),the emotional status,mental state,daily social interaction,work influence and total score of the treatment group were better than those of the control group(P<0.01).The scores of the treatment group were better than those of the control group(P<0.01);the scores and total scores of the treatment group were significantly improved after 4 weeks of treatment than those of the treatment group after 2 weeks of treatment(P<0.01),and the effects of daily exercise and diet of the control group were improved(P<0.05).5.Comparison of TCM syndrome efficacy:after 2 weeks of treatment,the scores and total scores of the treatment group were significantly improved compared with those before treatment(P<0.01),and the other scores and total scores of the control group were significantly improved compared with those before treatment(P<0.01).After 4 weeks of treatment,the scores and total scores of the two groups were significantly improved(P<0.01),and the treatment group was better than the control group in diarrhea,abdominal pain,breath and total scores(P<0.05,P<0.01).After 4 weeks of treatment,compared with 2 weeks of treatment,the scores and total scores of the treatment group were significantly improved(P<0.01),while those of the control group were improved except for depression and irritability(P0.05.P<0.01).6.Anxiety state comparison:after 2 weeks of treatment,the two groups were improved compared with before treatment(P<0.01);after 4 weeks of treatment,the scores of the two groups were significantly improved compared with before treatment(P<0.01),and the treatment group was better than the control group(P<0.01).After 4 weeks of treatment,the score of treatment group was significantly lower than that of 2 weeks of treatment(P<0.01),and the score of control group was also decreased(FAS:P<0.05,PPS:P<0.01,P<0.05).7.Comparison of depression:after 2 weeks of treatment,the scores of the two groups were significantly improved(P<0.01),the treatment group was better than the control group(FAS:P<0.01,P<0.05,PPS:P<0.01);after 4 weeks of treatment,the scores of the two groups were significantly decreased(P<0.01),and the treatment group was significantly better than the control group(P<0.01).After 4 weeks of treatment,compared with 2 weeks of treatment,the score of the treatment group was significantly lower(P<0.01),and the score of the control group was also decreased(FAS:P<0.05,PPS:P<0.01,P<0.05).Conclusion Xingpi Huashi Decoction can effectively treat IBS-D patients with spleen deficiency and dampness syndrome,effectively relieve the intestinal symptoms,improve the stool characteristics,improve the quality of life,relieve the syndrome of spleen deficiency and dampness,and relieve depression and anxiety. |
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