Correlation Between Target Organ Damage And Blood Pressure Variability In Patients With Prehypertension

Objective:To investigate the correlation between target organ damage and blood pressure variability in patients with prehypertension.Methods:A total of 194 patients diagnosed as prehypertension from November 2019 to November 2020 in the hypertension department of our hospital were selected,including 141 cases in the case group and 53 cases in the control group.According to the presence or absence of heart,brain,kidney and blood vessel damage,they were divided into heart damage group,brain damage group,kidney damage group and blood vessel damage group,respectively.The control group was the prehypertension group without any target organ damage.Patients’ basic data,test indexes,cardiac ultrasound,cervical vascular ultrasound,brain CT/MRI,and dynamic blood pressure indexes were collected,and the correlation between the variation of basic data,test indexes,blood pressure and target organ damage in each group was analyzed.Results:1.Comparison of age,height,weight,BMI,smoking,UA,TG,TC,HDL-C,LDL-C,Hcy,24 h SBPCV,24 h DBPCV,d SBPCV,24 h SBP and n SBP between the heart damage group and the control group showed statistical significance(P<0.05).24 h SBP elevation was a statistically significant risk factor for heart damage(P<0.05).2.There were statistically significant differences in age,height,weight,UA,TG,TC,HDL-C,LDL-C,Hcy,24 h SBPCV,d SBPCV,24 h SBP and n SBP between the brain damage group and the control group(P<0.05).24 h SBP was a statistically significant risk factor for brain damage(P <0.05).3.There were statistically significant differences in age,height,weight,BMI,gender,smoking,UA,TG,HDL-C,LDL-C,Hcy,24 h SBPCV and24 h SBP between the renal damage group and the control group(P <0.05).Smoking,elevated UA and Hcy were the risk factors for renal damage,which were statistically significant(P <0.05).4.There were statistically significant differences in body weight,FPG,TG,TC,LDL-C,24 h SBPCV,d SBPCV,24 h SBP and n SBP between the vascular damage group and the control group(P <0.05).Elevated FPG and 24 h SBPCV were risk factors for vascular damage,which were statistically significant(P <0.05).Conclusion: 1.Elevated 24 h SBP is a risk factor for heart and brain damage.2.Smoking,elevated UA and Hcy were the risk factors for renal damage,and no blood pressure variation was found to be associated with renal damage.3.Elevated FPG and 24 hSBPCV are risk factors for vascular damage.