Clinical Effect Of Vitamin D In The Treatment Of Migraine: A Meta-analysis

Background and ObjectiveMigraine is a neurovascular disorder that affects an estimated 1.04 billion people worldwide and is listed by the World Health Organization as the second most disabling disease in the world.Clinically,migraine is one of the common primary headaches,mostly presented as paroxysm,medium to a severe throbbing headache,often partial to one side,at the same time can appear nausea,vomiting,photophobia or fear of sound and other accompanying symptoms.Migraine sufferers tend to have a higher disease burden and a lower quality of life.For migraine patients,clinically often in order to reduce the frequency of headache,reduce recurrence,and concomitant symptoms for treatment purposes.At the same time,the side effects,dependence,treatment cost and patients’medication compliance caused by commonly used drugs are also paid close attention to by both doctors and patients.Vitamin D is one of the most common fat-soluble vitamins,and a lack of it has been linked to skeletal disorders in the previous cognition,however,more and more recent research evidences suggest that vitamin D plays a role in the treatment of migraine.With the deepening of exploration,some studies have cast doubt on the efficacy of vitamin D in treating migraine.This study conducted a meta-analysis of the included high-quality studies on the treatment of migraine with vitamin D to explore the therapeutic effect of vitamin D on migraine and analyze the correlation between the two,so as to provide more evidences for the clinical treatment of migraine.MethodsSystematically searching Pub Med,Web of Science,the Cochrane Library,Embase,China National Knowledge Infrastructure(CNKI),and Wanfang databases to obtain all studies on vitamin D treatment of migraine from the establishment to October 2020.The literature retrieved was strictly screened according to the pre-established inclusion and exclusion criteria,and relevant information and data were extracted from the final included studies,and each outcome index to be evaluated was recorded in detail.The above process was carried out by two researchers independently,and cross-check the data and results,through the third researcher intervention and discussion when necessary to resolve disputes.All included randomized controlled trials were assessed for risk of bias using the bias risk assessment tool recommended by the Cochrane book,and the quality of the included non-randomized trials was assessed using the NOS scale.Meta-analysis of this study was performed using Revman 5.3 software,and heterogeneity was tested and analyzed for each study result using I~2 quantitative test and Q test.The selection of fixed or random effect model was determined according to the level of heterogeneity.Subgroup analysis or sensitivity analysis could be further used to determine the source of heterogeneity among studies.The result of each outcome index was presented by forest plot.Results1.After searching,reading,and strict screening based on the inclusion and exclusion criteria,6 related studies were included,including 3 randomized controlled trials and 3 non-randomized trials,a total of 408 migraine patients were included.The results of this meta-analysis showed that the vitamin D group was better than the control group in reducing the frequency,number of days,duration and severity of migraine attacks,and the difference between the two groups was statistically significant(P<0.05).2.The results of a subgroup analysis by age showed that the vitamin D group was effective in both children and adults in reducing the frequency of migraine attacks,shortening the duration of each attack,and reducing the number of days of attack per month(P<0.05).3.Sensitivity analysis was conducted using the method that comparing whether the results were consistent before and after the change of the comparative effect model,and the results indicated that the results of this study were robust and reliable.Conclusions1.Vitamin D supplementation had a good clinical effect in treating migraine and could improve the clinical symptoms of patients.2.Age factor on the effect of vitamin D in the treatment of migraine had no obvious influence.