Analysis Of 11 Mineral Levels In Serum Of Children With Recurrent Respiratory Infection

ObjectiveThrough analyzing the contents of 11 minerals(calcium,iron,zinc,magnesium,copper,manganese,selenium,mercury,nickel,cobalt,lithium)in serum of 1～6 years old children with recurrent respiratory tract infection(RRTIs)and normal children,the relationship between RRTIs and 11 minerals(calcium,iron,zinc,magnesium,copper,manganese,selenium,mercury,nickel,cobalt,lithium)in serum was clarified in order to provide reference for the effective prevention of RRTIs.MethodsFrom September 2018 to December 2020,205 cases of recurrent respiratory tract infection in Shenyang Children’s Hospital were selected as RRTIs groups,According to the different stages of the course of disease,the children were divided into 148 cases of acute infection and 57 cases of non-acute infection;There were 141 cases of recurrent upper respiratory tract infection and 64 cases of recurrent lower respiratory tract infection(28 cases of recurrent pneumonia),Recurrent bronchitis(36 cases);In addition,212 healthy children were randomly selected as control group.Parents were asked to fill out a unified questionnaire,including:child name,sex,age,whether there are special diseases,nearly 6 months have been supplemented with trace elements.By inductively coupled plasma mass spectrometer(ICP-MS),the serum levels of 11elements were detected.The measurement data were measured by t test,expressed as((?)±s),and the counting data by χ~2 test,the difference was statistically significant(P<0.05)Results1.Compared with the control group,the contents of calcium,iron,zinc,selenium and nickel in the RRTIs group decreased significantly(P<0.01),and the contents of magnesium,copper,manganese,cobalt,mercury and lithium in RRTIs group were not significantly increased or decreased(P>0.05).2.The contents of iron,zinc,nickel and selenium decreased significantly in acute infection group compared with non-acute infection group(P<0.05),There was no significant increase or decrease in serum magnesium,copper,lithium,calcium,manganese,mercury and cobalt in acute infection group(P>0.05).3.The contents of serum calcium,iron,zinc and nickel in recurrent lower respiratory tract infection group were significantly decreased compared with those in recurrent upper respiratory tract infection group(P<0.05),and the contents of magnesium,copper,manganese,mercury,cobalt,selenium and lithium were not significantly increased or decreased(P>0.05).4.The proportion of zinc and iron deficiency in recurrent pneumonia group was significantly higher than that in recurrent bronchitis group(P<0.05),and there was no significant difference in calcium and nickel deficiency(P>0.05).Conclusions1.The contents of calcium,iron,zinc,selenium and nickel in the blood of RRTIs children were significantly lower than in healthy children.2.RRTIs the content of iron,zinc,nickel and selenium in children with acute attack is obviously lower than that in non-acute infection,it should be paid more attention to by clinicians and parents and replenish minerals in time.3.The contents of calcium,iron,zinc and nickel in children with recurrent lower respiratory tract infection were significantly lower than those in children with recurrent upper respiratory infection.4.Iron deficiency and zinc deficiency in children with 1.recurrent pneumonia were higher than that in recurrent bronchitis.5.RRTIs may be related to premature delivery,cesarean section,artificial feeding,asphyxia,irritability.