Clinical Significance Of α-synuclein And Serum Uric Acid In The Diagnosis Of Parkinson’s Disease And Vascular Parkinson’s Syndrome

ObjectiveThe plasma α-synuclein(α-syn)and Uric acid(Uric acid)were measured in patients with Parkinson’s Disease(PD)and Vascular parkinsonism(VP).UA)concentration detection,to observe the change rule in all groups,for clinical diagnosis of Parkinson’s disease to a biological marker,which provides the theoretical basis of early diagnosis and treatment of Parkinson’s disease,to identify Parkinson’s disease and vascular Parkinson’s syndrome provide theoretical foundation and provide help for clinical assessment of the severity of Parkinson’s disease.MethodA total of 60 PD patients(including 30 cases of mild and 30 cases of severe),60 VP patients,and 60 healthy subjects who underwent physical examination in the outpatient department of neurology and physical examination center during the period of May 2019 to December 2020 in our hospital were selected.Among them,PD patients met the diagnostic criteria of British Brain Bank for PD and VP patients met the diagnostic criteria of household standard for VP.General information such as gender and age of the included population was recorded.Enzyme Linked Immunosorbent Assay(ELISA)was used to detect α-synuclein in plasma of patients with Parkinson’s disease,vascular Parkinson’s syndrome and healthy controls,respectively,and serum uric acid level was determined by automatic biochemical analyzer.SPSS 26.0 software was used for data analysis.General data(gender,age),plasmaα-synuclein concentration and blood uric acid level were compared in the three groups.ResultsThe results showed that the plasma α-syn concentration in PD group was significantly higher than that in VP group and control group,and the difference was statistically significant(P<0.05).The plasma α-SYN concentration in mild PD group was lower than that in severe PD group,and the difference was statistically significant(P<0.05).There was no significant difference in plasma α-SYN concentration between VP group and control group(P > 0.05).The serum uric acid level in PD group was significantly lower than that in VP group and control group,and the difference was statistically significant(P<0.05).The serum uric acid level in VP group was significantly higher than that in control group,and the difference was statistically significant(P<0.05).The serum uric acid level in mild PD group was higher than that in severe PD group,and the difference was statistically significant(P<0.05).With the progression of Parkinson’s disease,the concentration of α-SYN increased and the level of UA decreased.Conclusionsα-synuclein is expected to be a biomarker for the early diagnosis of Parkinson’s disease,which provides a theoretical basis for the early diagnosis and treatment of Parkinson’s disease.The changes of α-synuclein and serum uric acid levels provide a theoretical basis for the differentiation between Parkinson’s disease and vascular Parkinson’s syndrome,and provide help for clinical evaluation of the severity of Parkinson’s disease.