Application Of Bushen Huoxue Recipe Combined With Estrogen And Progesterone Therapy After TCRA After Intrauterine Adhesion

Objective Compare the changes of clinical symptoms,TCM syndrome score and pregnancy rate of patients with intrauterine adhesions after TCRA treated with estrogen and progesterone alone and estrogen and progesterone combined with Bushen Huoxue Chinese medicine,and to study the clinical effect of Bushen Huoxue Chinese medicine on such patients,so as to optimize the current treatment of intrauterine adhesions after TCRA and provide new treatment ideas for clinical.Methods A collection of 76 patients with fertility requirements who met the diagnostic criteria for intrauterine adhesions in the gynecological inpatient department and outpatient department of Hubei Provincial Hospital of Traditional Chinese Medicine were collected.All patients were randomly divided into observation group and control group,and TCRA was performed uniformly.The control group was treated with estrogen and progesterone after the operation.The observation group was treated with Chinese herbal medicine for invigorating the kidney and promoting blood circulation on the basis of the control group for a total of 3 menstrual cycles.Record the menstrual volume,TCM syndrome score,and uterine adhesion degree,endometrial thickness,uterine artery PI,RI and other values before and after treatment in the two groups.After treatment for three menstrual cycles,review the hysteroscopy to understand the recovery rate of the uterine cavity and the overall curative effect.The postoperative follow-up was followed up for half a year to investigate the pregnancy rate of the two groups of patients.All data were analyzed statistically to analyze the total clinical effectiveness of the two treatment methods.Result 1.Month mass comparison: The average rating of the menstrual blood loss of the observation group was42.24±16.58 points,and the control group was 36.75±18.92 points,The average points of observation group after treatment were significantly better than that of the control group,and the difference was statistically significant(P <0.01).2.Comparison of TCM syndrome scores: The TCM syndromes such as "low menstrual flow,backache,soft knees,lower abdomen pain,and menstrual blood entrapment" were improved in the two groups.The syndrome scores of the observation group were significantly lower than those of the control group(P<0.01).3.Comparison of Endometrial thickness: The endometrial thickness of the two groups of patients was significantly increased compared to before treatment.After comparison between the groups,the endometrial thickness of the observation group was significantly increased than that of the control group,and the difference was statistically significant(P<0.05).4.Comparison of Uterine artery PI,RI: The PI and RI of the bilateral uterine arteries decreased after treatment in the two groups(P<0.05).Moreover,the PI and RI of the bilateral uterine arteries in the observation group decreased more significantly than those in the control group,and the difference was statistically significant(P<0.05)5.Comparison of uterine cavity recovery rates: The hysteric recovery rate of the observation group was as high as83.3%,which was statistically significant than 63.9% of the control group(P<0.05).Among them,mild adhesion patients,hysteric recovery rates,good prognosis,and observation group,the uterine recovery rate of patients with severe adhesion was higher than that of the control group,and the difference was statistically significant(P <0.05)6.Comparison of pregnancy rates: Followed up for half a year after treatment,the total pregnancy rate of the observation group was 52.8%,and the total pregnancy rate of the control group was 30.6%.The difference between the two groups was statistically significant(P<0.05).7.Comparison of overall clinical efficacy: The total clinical effective rate of the observation group was 86.1%,and the total clinical effective rate of the control group was 69.4%.The observation group was significantly better than the control group(P<0.01).8.Safety analysis:During the treatment,one patient in the control group had a slight increase in liver function,and stopped the study.None of the remaining patients suffered from dizziness,headache,nausea,vomiting and other gastrointestinal symptoms,and did not complain of appetite change or discomfort in stool,which proved that the treatment was relatively safe.Conclusions Bushen Huoxue Chinese medicine combined with estrogen and progesterone therapy can significantly improve menstrual flow and TCM symptoms of patients with intrauterine adhesions after TCRA,promote endometrial repair,increase uterine artery blood flow resistance,and increase uterine cavity recovery rate and pregnancy rate,The curative effect is obviously better than that of estrogen and progesterone alone.The method of combining traditional Chinese and Western medicine has good safety,no side effects,and can also improve the patient’s systemic symptoms comprehensively.It is worthy of clinical promotion and application.