| Objective By observing the therapeutic effect of Pingwei Jiangni Decoction on gastroesophageal reflux disease(GERD)of spleen deficiency and damp-heat syndrome,this study discusses and analyzes the rationality and advantages of Pingwei Jiangni Decoction in the treatment of GERD of spleen deficiency and damp-heat syndrome,and provides new methods and ideas for the prevention and treatment of GERD of spleen deficiency and dampness-heat syndrome with traditional Chinese medicine.Methods A total of 60 patients with GERD were selected in the clinical trial from May 2019 to September 2020 in the outpatient clinical of Wuhan Hospital Of Traditional Chinese and Western Medicine,they were diagnosed as GERD by various examinations and were diagnosed as spleen deficiency and damp-heat syndrome by TCM syndrome differentiation.They were randomly divided into two groups.There was no significant differences in gender,age,Duration of disease between the treatment group and the control group(P>0.05).The treatment group was given Pingwei Jiangni Decoction,which was decocted by the Chinese Medicine Pharmacy of Wuhan Hospital Of Traditional Chinese and Western Medicine,200ml/bag,1 dose per day,1 bag at a time,2 times a day,30 minutes after breakfast and dinner.And the control group was orally administered with 40 mg pantoprazole sodium enteric-coated capsules once a day.All participants must give up smoking,alcohol and thick tea during the experiment,avoid spicy,cold and irritant food,avoid immediately bedridden after eating,and try to raise the head of the bed during bed rest.They should communicate with the researchers when taking other drugs or adding drugs due to special circumstances.8 weeks of treatment is a course of treatment.After 1 course of treatment,the efficacy and safety are evaluated.Results:1.The efficacy of single symptom:The scores of several symptoms in the treatment group,such as acid reflux,chest distress,uncomfortable diet,fatigue,and loose stools,were significantly lower than those in the control group(P<0.05),indicating that the efficacy of Pingwei Jiangni Decoction in the treatment of acid reflux,chest distress,uncomfortable diet,fatigue,and loose stools was better than that of pantoprazole sodium enteric-coated capsules.2.Total symptom score :There was a significant difference in total symptom score between the two groups after treatment(P<0.01),indicating that the efficacy of the TCM group was significantly better than that of the western medicine group.3.Total effective rate : the total effective rate of treatment group was 93.33 %,including 9 cases cured,16 cases markedly effective,3 cases effective,2 cases ineffective;The total effective rate of the control group was 83.33%,including 3 cases cured,13 cases markedly effective,9 cases effective and 5 cases ineffective.There was a significant difference in the total effective rate between the treatment group and the control group after treatment(P<0.05),and the effect of the treatment group was better than that of the control group.4.Recurrence rate: The two groups had a return visit 4 weeks after the end of treatment.The recurrence rate of the treatment group was14.29 %,and that of the control group was 36.00%.The recurrence rate of the treatment group was significantly lower than that of the control group,and the recurrence rate of the two groups was statistically significant(P<0.05).Conclusion Pingwei Jiangni Decoction and pantoprazole sodium enteric-coated tablets have good therapeutic effects on GERD of spleen deficiency and damp-heat syndrome.but Pingwei Jiangni Decoction has better therapeutic effects than pantoprazole sodium enteric-coated tablets in improving symptoms such as acid reflux,chest distress,uncomfortable diet,fatigue,and loose stools.No adverse events occurred in both groups during the study.It is proved that Pingwei Jiangni Decoction in the treatment of GERD of spleen-deficiency and damp-heat syndrome are effective,safe and reliable,and it is worthy of reference,application and promotion by clinicians. |
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