Research On Synthesis Of Organic Azides By 1,6-conjugation Addition Of δ-CF3-p-QMs

p-QM is an important quinone derivative,which is widely found in natural products,such as plant pigments,terpenes,fungal metabolites and so on.This type of compound has anti-tumor,anti-bacterial,Anti-fungal,anti-viral,anti-parasitic,anti-inflammatory,anti-oxidant and other activities.In this experiment,organic azides were synthesized by1,6-conjugated addition ofδ-CF₃-p-QMs.Organic azides have antibacterial and antiviral activities,for example,the commonly used broad-spectrum antibacterial drug adexillin and the antiviral drug zidovudine,which play an important role in the prevention and treatment of animal diseases.In this experiment,organic azides were synthesized through the 1,6-conjugation addition byδ-CF₃-p-QMs.The catalysts and solvents that affect the reaction activity were screened,and the reaction conditions of sodium carbonate as the catalyst and acetone as the solvent were established.A new method for the synthesis of organic azides based on the1,6-conjugation addition ofδ-CF₃-p-QMs was established.22δ-CF₃-p-QMs were subjected to azide modification to synthesize 22 organic azides by this method with a yield of 87%-96%.In this experiment,the synthesizedδ-CF₃-p-QMs and organic azides were confirmed by¹H-NMR,¹³C-NMR,¹⁹F-NMR and HRMS.In this experiment,a new method for the synthesis of organic azides based on the1,6-conjugate addition ofδ-CF₃-p-QMs was established.This method has mild condition,rapid response,safety and efficiency.The synthesized 22 organic azides provide a material basis for the subsequent screening of active drugs.